Effects of anesthetics on statin-induced endothelial protection in diabetic and hypertensive rat.

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19591815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: OGAWA Koji Wakayama Medical University, 医学部, 准教授 (30204077)
• Project Period (FY): 2007 – 2010
• Keywords: スタチン / 糖尿病 / 血管内皮細胞 / 一酸化窒素

Research Abstract

本研究では動脈硬化モデルとして自然発症型糖尿病および高血圧ラットを用い、スタチンの短期的および長期投与による内皮機能改善作用に及ぼす麻酔薬(セボフルラン、イソフルラン、プロポフォール、チオペンタール)の影響を比較し、その機序を解明する。

Research Products

• [Journal Article] Differential vasodilation response to olprinone in rabbit renal and common carotid arteries (2010)
  • Author(s): Minonishi T, Ogawa K, Tokinaga Y, Negoro T, Kimoto Y, Hatano Y
  • Journal Title: J Anesth 24 Pages: 61-66
  • Peer Reviewed
• [Journal Article] Volatile Anesthetics Inhibit Angiotensin II-induced Vascular Contraction by Modulating Myosin Light Chain Phosphatase Inhibiting Protein, CPI-17 and Regulatory Subunit, MYPT1 Phosphorylation (2009)
  • Author(s): Qi Feng, Ogawa K, Tokinaga Y, Uematsu N, Minonishi T, Hatano Y
  • Journal Title: Anesth Analg 109 Pages: 412-417
  • Peer Reviewed
• [Presentation] Sevoflurane inhibits the increase in statin-Induced endothelial nitric oxide synthase expression (2009)
  • Author(s): Tange K, Tokinaga Y, Ogawa K, Hatano Y
  • Organizer: 2009 Annual Meeting of Anerican Society of Anesthesiologists
  • Place of Presentation: 米国ルイジアナ州ニューオリンズ
  • Year and Date: 2009-10-17
• [Presentation] Simvastatin restores the impaired endothelium-dependent relaxation in diabetic rats (2009)
  • Author(s): Sugimoto K, Ogawa K, Tokinaga Y, Tange K, Hatano Y
  • Organizer: 2009 Annual Meeting of Anerican Society of Anesthesiologists
  • Place of Presentation: 米国ルイジアナ州ニューオリンズ
  • Year and Date: 2009-10-17
• [Presentation] ウシ大動脈内皮細胞における一酸化窒素 (NO) 産生量に対するシンバスタチンの急性効果 (2009)
  • Author(s): 丹下和晃, 時永泰行, 井上真理子, 佐古有希子, 小川幸志, 畑埜義雄
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-08-17
• [Presentation] シンバスタチンは糖尿病における内皮依存性弛緩反応低下を回復させる (2009)
  • Author(s): 時永泰行、小川幸志、木本吉紀、槙野仁奈、阪中容、畑埜義雄
  • Organizer: 日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-08-16