2010 Fiscal Year Final Research Report
The anesthetic modulation of the protective effect of statin on the endothelium function in diabetic and hypertensive animal models.
| Project/Area Number |
19591815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
OGAWA Koji Wakayama Medical University, 医学部, 准教授 (30204077)
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| Co-Investigator(Kenkyū-buntansha) |
MIZUMOTO Kazuhiro 和歌山県立医科大学, 医学部, 准教授 (50239258)
HATANO Yoshio 和歌山県立医科大学, 医学部, 教授 (70115913)
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| Project Period (FY) |
2007 – 2010
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| Keywords | スタチン / 血管内皮細胞 / 一酸化窒素 / 揮発性麻酔薬 / 糖尿病 |
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| Research Abstract |
Exposure of cultured endothelial cells to simvastatin induced NO production. The increase in NO production was significantly inhibited in the presence of sevoflurane. Sevoflurane also inhibited increase in eNOS expression in response to simvastatin, but not eNOSmRNA expression. It is suggested the transcriptional modification of eNOS may be involved in the statin-induced activation of eNOSNO signaling pathways. Sevoflurane appears to affect this process.
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