2008 Fiscal Year Final Research Report
Roles of a mechano-sensitive ion channel, TRPA1, in the bladder sensory transduction
| Project/Area Number |
19591840
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
ARAKI Isao University of Yamanashi, 大学院・医学工学総合研究部, 准教授 (50252424)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hideki 山梨大学, 大学院・医学工学総合研究部, 助教 (50402053)
TAKEDA Masayuki 山梨大学, 大学院・医学工学総合研究部, 教授 (80197318)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 排尿障害 / イオンチャネル / 膀胱 / 知覚神経 / 前立腺肥大症 / 下部尿路閉塞 / 過活動膀胱 |
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| Research Abstract |
本研究課題における実験結果から、膀胱上皮あるいは膀胱粘膜下知覚神経終末に発現するTRPA1が膀胱知覚神経伝達(尿意)に関与していると考えられた。さらに、ヒト閉塞膀胱上皮に過剰発現するTRPA1が閉塞膀胱における過活動膀胱発生機序に関与している可能性を示唆している。したがって, TRPA1に特異的なアンタゴニストの開発は, 過活動膀胱などの排尿障害に対する新しい治療薬の開発に繋がるものと期待される。
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[Journal Article] Defining overactive bladder as hypersensitivity2007
Author(s)
Yamaguchi O, Honda K, Nomiya M, Shishido K, Kakizaki H, Tanaka H, Yamanishi T, Homma Y, Takeda M, Araki I, Obara K, Nishizawa O, Igawa Y, Goto M, Yokoyama O, Seki N, Takei M, Yoshida M
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Journal Title
Neurourol Urodyn 26(6 Suppl)
Pages: 904-907
Peer Reviewed
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[Presentation] Contribution of acid-sensing ion channels to gender difference in mouse bladder response to acetic acid : a novel candidate for interstitial cystitis2008
Author(s)
Kobayashi H, Yoshiyama M, Araki I, Zakoji H, Sawada N, Mochizuki T, Tsuchida T, Nomura T, Fukasawa M, Takeda M
Organizer
American Urological Association 103rd annual meeting
Place of Presentation
Orland, FL, USA
Year and Date
20080517-22
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[Presentation] Predictive factors for the effect of alpha1- adrenoceptor antagonist on subjective and objective parameters in patients with neurogenic lower urinary tarct dysfunction : special focus on alpha1-D/A adrenoceptor antagonist naftopidil2007
Author(s)
Araki I, Takeda M, Homma Y, Gotoh M, Igawa Y, Seki N, Takei M, Yoshida M, Kakizaki H, Yamanishi T, Sugaya K, Nishizawa O
Organizer
International Continence Society 37th Annual Meeting
Place of Presentation
Rotterdam, Netherlands
Year and Date
20070820-24
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[Presentation] Acid-sensing ion channel : expression changes in the urinary bladder following chronic bladder inflammation2007
Author(s)
Kobayashi H, Araki I, Zakoji H, Du S, Sawada N, Mochizuki T, Yoshiyama M, Tsuchida T, Nomura T, Fukasawa M, Takihana Y, Takeda M
Organizer
International Continence Society 37th Annual Meeting
Place of Presentation
Rotterdam, Netherlands
Year and Date
20070820-24
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