2010 Fiscal Year Final Research Report
Influence of immunotherapy with interferon-alpha and the efficacy of interferon combined with dendritic therapy on renal cell carcinoma
| Project/Area Number |
19591855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
TATSUGAM Katsunor Kyushu University, 大学病院, 講師 (90380617)
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| Co-Investigator(Kenkyū-buntansha) |
ETO Masatoshi 九州大学, 大学病院, 講師 (90315078)
HARANO Masahiko 九州大学, 大学病院, 助教 (90380451)
HAMAGUCHI Masukitsu 九州大学, 大学病院, 医員 (40419578)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 腎細胞癌 / 免疫療法 / インターフェロン / 樹状細胞 / 抑制性T細胞 |
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| Research Abstract |
We examined the efficacy of immunotherapy combined with cytokines (IFN-a and IL-2) and the impact of the immunotherapy on host immunity in RCC patients. We found that regulatory T cells result in inducing negative effect in recipients received with immunotherapy such as cytokine-therapy or nonmyeloablative allogeneic cell therapy. We also indicated that targeted drugs- or dendritic cells-therapy combined with IFN-a administration is feasible and safe, and the treatment has the potential for prolonging the time to progression in advanced RCC.
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[Journal Article] Posttransplant administration of cyclophosphamide and donor lymphocyte infusion induces potent antitumor immunity to solid tumor.2008
Author(s)
Eto M, Kamiryo Y, Takeuchi A, Harano M, Tatsugami K, Harada M, Kiyoshima K, Hamaguchi M, Teshima T, Tsuneyoshi M, Yoshikai Y, Naito S.
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Journal Title
Clin Cancer Res 14(9)
Pages: 2833-2840
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[Remarks] ホームページ等
