2009 Fiscal Year Final Research Report
Identification of the genes causing azoospermia in human and analysis of the mechanism in spermatogenesis
| Project/Area Number |
19591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
MIYAMOTO Toshinobu Asahikawa Medical College, 医学部, 助教 (70360998)
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| Co-Investigator(Kenkyū-buntansha) |
SENGOKU Kazuo 旭川医科大学, 医学部, 教授 (30163124)
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| Project Period (FY) |
2007 – 2009
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| Keywords | azoospermia / mutation / SNP / spermatogenesis |
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| Research Abstract |
One of the most serious social problems facing Japan today is the declining birth rate. However, it is generally not well recognized that the number of infertile couples is on the rise in advanced nations. One of the most serious causes for infertility is male factor. Therefore, we analyzed the genes causing human azoospermia, especially meiosis. It was suggested that the human MEISETZ, PARP-2 and SPATA17 play critical roles in spermatogenesis, especially meiosis.
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