2009 Fiscal Year Final Research Report
Study on the mechanisms of human placental trophoblast syncytialisation : implication for the pathogenesis of pre-eclampsia
Project/Area Number |
19591895
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Hiroshima University |
Principal Investigator |
KUDO Yoshiki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (80241082)
|
Co-Investigator(Kenkyū-buntansha) |
MIYOSHI Hiroshi 広島大学, 大学院・医歯薬学総合研究科, 講師 (40294590)
NOBUZANE Takahiro 広島大学, 病院, 助教 (80403559)
|
Project Period (FY) |
2007 – 2009
|
Keywords | 胎盤 / トロフォブラスト / 妊娠高血圧症候群 |
Research Abstract |
We have demonstrated that CD98 surface antigen, syncytin, an envelope gene of HERV-W (human endogenous retrovirus-W), and its receptor type D mammalian retrovirus receptor (ASCT2) are involved in the process of cell fusion necessary for syncytiotrophoblast formation using a cell model of syncytialisation (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin treatment).
|
Research Products
(13 results)