2009 Fiscal Year Final Research Report
Metabolic syndrome and endometrial cancer-PPARγ ligands as useful drug candidates for endocrine treatment-
| Project/Area Number |
19591921
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tohoku University |
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Principal Investigator |
ITO Kiyoshi Tohoku University, 大学院・医学系研究科, 准教授 (70241594)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Satoshi 東北大学, 病院, 臨床検査技師 (40420020)
ABE Keiko 東北大学, 未来医工学治療開発センター, 臨床検査技師 (30444003)
SUZUKI Fumihiko 東北大学, 大学院・医学系研究科, 助教 (20400343)
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| Project Period (FY) |
2007 – 2009
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| Keywords | Peroxisome Proliferator-Activated Receptor (PPAR) / 子宮内膜癌 / メタボリックシンドローム / PPAR活性剤 / アロマターゼ / レチノイド / 癌-間質相互作用 / コーヒー |
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| Research Abstract |
The inspection from the viewpoint of metabolic syndrome is useful for the sorting of the endometrial cancer risk. In addition, PPARγ ligands, known as the metabolic syndrome therapeutic drugs, and the agonists of retinoid receptors forming heterodimerization with PPAR, should be important drug candidates for endocrine treatment of endometrial cancer. On the other hand, we indicated aromatase played a very important role in the local biosynthesis of estrogen in human endometrial cancer through tumor-stromal cell interactions. Therefore, aromatase inhibitors should be useful drugs especially for patients with endometrial cancers, which have aromatase activities.
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[Journal Article] Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma2009
Author(s)
Kakuta Y, Nakaya N, Nagase S, Fujita M, Koizumi T, Okamura C, Niikura H, Ohmori K, Kuriyama S, Tase T, Ito K, Minami Y, Yaegashi N, Tsuji I.
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Journal Title
Cancer Causes Control. 20
Pages: 617-24
Peer Reviewed
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[Journal Article] The expression of retinoic acid receptors in human endometrial carcinoma2008
Author(s)
Tanabe K, Utsunomiya H, Tamura M, Niikura H, Yoshinaga K, Takano T, Suzuki T, Nagase S, Ito K, Matsumoto M, Hayashi S, Yaegashi N.
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Journal Title
Cancer Sci. 99
Pages: 267-71
Peer Reviewed
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[Journal Article] Case-control study of coffee consumption and the risk of endometrial endometrioid adenocarcinoma2008
Author(s)
Koizumi T, Nakaya N, Okamura C, Sato Y, Shimazu T, Nagase S, Niikura H, Kuriyama S, Tase T, Ito K, Tsubono Y, Okamura K, Yaegashi N, Tsuji I.
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Journal Title
Eur J Cancer Prev. 17
Pages: 358-63
Peer Reviewed
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[Journal Article] Estrogen signaling ability in human endometrial cancer through the tumor-stromal interaction2008
Author(s)
Matsumoto M, Yamaguchi Y, Seino Y, Hatakeyama A, Takei H, Niikura H, Ito K, Suzuki T, Sasano H, Yaegashi N, Hayashi S.
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Journal Title
Endocr Relat Cancer 15
Pages: 451-63
Peer Reviewed
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[Journal Article] Smoking, earlier menarche and low parity as independent risk factors for gynecologic cancers in Japanese : a case-control study2008
Author(s)
Fujita M, Tase T, Kakugawa Y, Hoshi S, Nishino Y, Nagase S, Ito K, Niikura H, Yaegashi N, Minami Y.
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Journal Title
Tohoku J Exp Med. 216
Pages: 297-307
Peer Reviewed
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[Journal Article] Midkine and its clinical significance in endometrial carcinoma2008
Author(s)
Tanabe K, Matsumoto M, Ikematsu S, Nagase S, Hatakeyama A, Takano T, Niikura H, Kadomatsu K, Ito K, Hayashi S, Yaegashi N.
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Journal Title
Cancer Sci. 99
Pages: 1125-30
Peer Reviewed
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