The role of laminin peptides for acquirement of metastasis of the free floating of ovarian cancer spheroids

2008 Fiscal Year Final Research Report

• Project/Area Number: 19591928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Fukui
• Principal Investigator: YOSHIDA Yoshio University of Fukui, 医学部, 准教授 (60220688)
• Co-Investigator(Kenkyū-buntansha): SAWAMURA Yoko 福井大学, 医学部・産婦人科, 助教 (40436845) ; SHINAGAWA Akiko 福井大学, 医学部・産婦人科, 助教 (90444223)
• Research Collaborator: HYNDA H Kleinmann, NIH, 教授
• Project Period (FY): 2007 – 2008
• Keywords: 卵巣がん / laminin peptide syndecan-1 cisplatin

Research Abstract

AG73T laminin peptideはシスプラチンの作用を増強し、卵巣がんの新たな治療法になる可能性がある

Research Products

• [Journal Article] Laminin-1-derived scrambled peptide AG73T disaggregates laminin-1-induced ovarian cancer cell spheroids and improves the efficacy of cisplatin (2008)
  • Author(s): Yoshida Y, Kurokawa T, Nishikawa Y, Orisa M, Kleinman HK, Kotsuji F
  • Journal Title: Int J Oncol 32(3) Pages: 673-81
  • Peer Reviewed
• [Presentation] Hynda K Kleinmann A potent peptide antagonist to an active laminin-1 sequence and cisplatin synergize in down regulation of Bcl-2/Bax ratios induction of apoptosis in human ovarian cancer cells (2008)
  • Author(s): Yoshida Y, Kurokawa T, Kotsuji F
  • Organizer: 13 World Congress on Advances in Oncology
  • Place of Presentation: Greece
  • Year and Date: 20080000
• [Presentation] Hynda K Kleinmann Laminin-1 derived AG73 peptides inhibited formation of multicellular spheroids of free-floating ovarian cancer cells (2007)
  • Author(s): Yoshida Y, Yagihara A, Kurokawa T, Kotsuji F
  • Organizer: Proceedings of American
  • Place of Presentation: USA
  • Year and Date: 20070000