2009 Fiscal Year Final Research Report
Investigation for ovarian cancer therapy focusing on production of human chorionic gonadotropin beta subunit
| Project/Area Number |
19591938
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kumamoto University |
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Principal Investigator |
TASHIRO Hironori Kumamoto University, 医学部附属病院, 講師 (70304996)
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| Co-Investigator(Kenkyū-buntansha) |
KATABUCHI Hidetaka 熊本大学, 大学院・生命科学研究部, 教授 (90224451)
OHTAKE Hideyuki 熊本大学, 医学部附属病院, 助教 (60336237)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 婦人科腫瘍学 |
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| Research Abstract |
Most patients with ovarian cancer are diagnosed at an advanced stage. Although treatment for ovarian cancer consists of surgical treatment and combination chemotherapy, there is still poor prognosis associated with drug resistance. As an experimental model system for epithelial ovarian carcinogenesis, we established immortalized human ovarian surface epithelial (OSE) cell lines. Using this system, we clarified the production of hCG α subunit and β subunit in the OSE cells, and the effect of hCG β subunit in anchorage-independent growth of the OSE cells. Moreover, many ovarian cancer tissues also expressed hCG β subunit. This discovery will provide a development of new therapeutic strategies for ovarian cancer.
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[Journal Article] Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations.2008
Author(s)
Sangha N, Wu R, Kuick R, Powers S, Mu D, Fiander D, Yuen K, Katabuchi H, Tashiro H, Fearon ER, Cho KR.
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Journal Title
Neoplasia 10
Pages: 1362-1372
Peer Reviewed
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