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2009 Fiscal Year Final Research Report

Spoken language development in the pediatric brain and its plastic reorganization induced by deafness

Research Project

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Project/Area Number 19592002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionFoundation for Biomedical Research and Innovation

Principal Investigator

NAITO Yasushi  Foundation for Biomedical Research and Innovation, 分子イメージング研究グループ, 客員研究員 (70217628)

Co-Investigator(Kenkyū-buntansha) SENDA Michio  先端医療振興財団, 分子イメージング研究グループ, グループリーダー (00216558)
UJIWARA Keizo  先端医療振興財団, 分子イメージング研究グループ, 客員研究員 (10443566)
Project Period (FY) 2007 – 2009
Keywords音声言語 / 脳機能 / 発達 / FDG-PET / 聴覚障害 / 可塑性
Research Abstract

Objectives : To investigate the cortical processing of the visual component of language and the effect of deafness upon this activity. Subjects and methods : Six prelingually deafened children participated in this study. The subjects were numbered 1 to 6 in the order of their spoken communication skills. In the time period between an intravenous injection of 370 MBq 18F-FDG and PET scanning of the brain, each subject was instructed to watch a video of the face of a speaking person. The cortical radioactivity of each deaf child was compared with that of a group of normal-hearing adults using at test in a basic SPM2 model. Results : The widest bilaterally activated cortical area was detected in subject 1, who was the worst user of spoken language. By contrast, there was no significant difference between subject 6, who was the best user of spoken language with a hearing aid, and the normal hearing group. Conclusions : The use of fluorodeoxyglucose positron emission tomography (FDG-PET) with a visual language task provided objective information on the development and plasticity of cortical language networks. This approach could help individuals involved in the habilitation and education of prelingually deafened children to decide upon the appropriate mode of communication.

  • Research Products

    (36 results)

All 2010 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (24 results) Book (2 results)

  • [Journal Article] Cortical activation during optokinetic stimulation-an fMRI study2009

    • Author(s)
      Kikuchi M, Naito Y, Senda M, et al
    • Journal Title

      Acta Oto-Laryngologica 129

      Pages: 440-443

    • Peer Reviewed
  • [Journal Article] 高度難聴小児における皮質聴覚言語野の発達2008

    • Author(s)
      内藤泰、藤原敬三
    • Journal Title

      Otol Jpn 18

      Pages: 19-22

    • Peer Reviewed
  • [Journal Article] 最近10年間の感音難聴児の病因と発症率2008

    • Author(s)
      吉岡三恵子、内藤泰
    • Journal Title

      日本小児科学会雑誌 112

      Pages: 1813-1817

    • Peer Reviewed
  • [Journal Article] 【補聴器と人工内耳最近の進歩と将来展望】人工内耳の最新知見高次能機能からみた人工内耳2008

    • Author(s)
      内藤泰、藤原敬三、眞鍋朋子、東田海
    • Journal Title

      JOHNS 24(9)

      Pages: 1401-1406

  • [Journal Article] 【難聴の神経学】難聴者の脳機能2008

    • Author(s)
      内藤泰
    • Journal Title

      神経内科 68(5)

      Pages: 456-462

  • [Journal Article] Brain metabolism of children with profound deafness: a visual language activation study by 18F-fluorodeoxyglucose positron emission tomography2008

    • Author(s)
      Fujiwara K, Naito Y, Senda M, Mori T, Manabe T, Shinohara S, Kikuchi M, Hori S, Tona Y, Yamazaki H
    • Journal Title

      Acta Otol 128

      Pages: 393-397

    • Peer Reviewed
  • [Journal Article] Effect of amplitude modulation of background noise on auditory-evoked magnetic fields2008

    • Author(s)
      Hiraumi H, Nagamine T, Morita T, Naito Y, Fukuyama H, Ito J
    • Journal Title

      Brain research 1239

      Pages: 191-197

    • Peer Reviewed
  • [Journal Article] 【聴覚とコミュニケーション】聴覚コミュニケーションと脳機能2007

    • Author(s)
      藤木暢也、内藤泰
    • Journal Title

      音声言語医学 48(3)

      Pages: 277-283

    • Peer Reviewed
  • [Journal Article] A recovery from enhancement of activation in auditory cortex of patients with idiopathic sudden sensorineural hearing loss2007

    • Author(s)
      Morita T, Hiraumi H, Fujiki N, Naito Y, Nagamine T, Fukuyama H, Ito J
    • Journal Title

      Neuroscience Research 58

      Pages: 6-11

    • Peer Reviewed
  • [Journal Article] Correlation between middle-ear pressure-regulation functions and outcome of type-I tympanoplasty2007

    • Author(s)
      Takahashi H, Sato H, Nakamura H, Naito Y, Umeki H
    • Journal Title

      Auris Nasus Larynx 34(2)

      Pages: 173-6

    • Peer Reviewed
  • [Presentation] 聴覚口語法による指導を行った小児人工内耳自験例15例の長期言語成績2010

    • Author(s)
      諸頭三郎、内藤泰、眞鍋朋子、山本輪子、山崎博司、藤原敬三、篠原尚吾、菊地正弘、栗原理紗、金沢佑治
    • Organizer
      第164回日耳鼻兵庫県地方部会
    • Place of Presentation
      尼崎市
    • Year and Date
      2010-03-28
  • [Presentation] Evaluation of cortical processing of language by use of positron emission tomography in patients with known hearing loss etiology2009

    • Author(s)
      Moteki H, Naito Y, Usami S
    • Organizer
      th Asia Pacific Symposium on Cochlear Implants and Related Sciences (APSCI 2009)
    • Place of Presentation
      Singapore
    • Year and Date
      20091201-20091204
  • [Presentation] 遺伝子と脳機能が評価できた人工内耳装用児のコミュニケーション行動と発声の変化2009

    • Author(s)
      鈴木美華、茂木英明、工穣、宇佐美真一、内藤泰、前田麻貴、北野庸子
    • Organizer
      第54回日本聴覚医学会
    • Place of Presentation
      横浜市
    • Year and Date
      20091022-20091023
  • [Presentation] 嚢胞状の蝸牛形態を示す高度内耳奇形例における人工内耳装用効果について2009

    • Author(s)
      山崎博司、内藤泰、篠原尚吾、藤原敬三、菊地正弘、眞鍋朋子、東田海、諸頭三郎
    • Organizer
      第54回日本聴覚医学会
    • Place of Presentation
      横浜市
    • Year and Date
      20091022-20091023
  • [Presentation] 原因や経過の異なる難聴患者における脳代謝の違いPETによる検討2009

    • Author(s)
      茂木英明、鬼頭良輔、西尾信哉、工穣、宇佐美真一、藤原敬三、内藤泰
    • Organizer
      第19回日本耳科学会
    • Place of Presentation
      東京都
    • Year and Date
      20091008-20091010
  • [Presentation] 先天性サイトメガロウィルス(CMW)感染症における進行性及び遅発性難聴について2009

    • Author(s)
      吉岡三恵子、内藤泰
    • Organizer
      第242回日本小児科学会兵庫県地方部会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-05-19
  • [Presentation] 脳機能から見た難聴と人工内耳(招待講演)2009

    • Author(s)
      内藤泰
    • Organizer
      東京医大病院聴覚・人工内耳センター年次フォーラム
    • Place of Presentation
      東京都
    • Year and Date
      2009-04-11
  • [Presentation] 内耳奇形例の人工内耳手術-電極の選択と挿入法-2008

    • Author(s)
      内藤泰、藤原敬三、篠原尚吾、菊地正弘、堀真也、山崎博司
    • Organizer
      第18回日本耳科学会
    • Place of Presentation
      神戸市
    • Year and Date
      20081016-20081018
  • [Presentation] 広汎性発達障害児の人工内耳2008

    • Author(s)
      眞鍋朋子、東田海、内藤泰、篠原尚吾、藤原敬三、菊地正弘、堀真也、山崎博司
    • Organizer
      第53回日本聴覚医学会
    • Place of Presentation
      東京
    • Year and Date
      20081002-20081003
  • [Presentation] 人工内耳前後での先天性高度難聴小児の脳代謝の変化-PETによる計測-2008

    • Author(s)
      藤原敬三、内藤泰、篠原尚吾、菊地正弘、堀真也、山崎博司、眞鍋朋子、東田海
    • Organizer
      第53回日本聴覚医学会
    • Place of Presentation
      東京
    • Year and Date
      20081002-20081003
  • [Presentation] 遺伝子と脳機能が評価できた先天性難聴症例2008

    • Author(s)
      茂木英明、鬼頭良輔、菊池景子、工穣、宇佐美真一、内藤泰、前田麻貴、北野庸子
    • Organizer
      第53回日本聴覚医学会
    • Place of Presentation
      東京
    • Year and Date
      20081002-20081003
  • [Presentation] An fMRI study on cortical activation during optokinetic stimulation2008

    • Author(s)
      Naito Y, Kikuchi M, Senda M, Shinohara S, Fujiwara K, Hori S, Tona Y, Yamazaki H
    • Organizer
      Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      20080824-20080827
  • [Presentation] Changes of Brain Metabolism of a Profoundly Deafened Child: Visual Language Activation Study before and after Cochlear Implantation2008

    • Author(s)
      Fujiwara K, Naito Y, Manabe T, Senda M, Shinohara S, Kikuchi M, Hori S, Tona Y, Yamazaki H
    • Organizer
      XV Barany Society Meeting
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      20080331-20080403
  • [Presentation] 広汎性発達障害児の人工内耳2008

    • Author(s)
      眞鍋朋子、東田海、内藤泰、篠原尚吾、藤原敬三、菊地正弘、堀真也、十名洋介、山崎博司
    • Organizer
      第159回日耳鼻兵庫県地方部会
    • Place of Presentation
      神戸市
    • Year and Date
      2008-07-05
  • [Presentation] 難聴の聴覚機能と脳のイメージング(招待講演)2008

    • Author(s)
      内藤泰
    • Organizer
      第20回愛媛ヒアリング研究会(EHA)
    • Place of Presentation
      松山
    • Year and Date
      2008-03-09
  • [Presentation] 難聴者の脳機能(招待講演)2008

    • Author(s)
      内藤泰
    • Organizer
      長崎ニューロサイエンス研究会
    • Place of Presentation
      長崎市
    • Year and Date
      2008-02-16
  • [Presentation] 人工内耳による聞こえの回復(招待講演)2008

    • Author(s)
      内藤泰
    • Organizer
      神戸市立聴覚障害者情報センター
    • Place of Presentation
      神戸市
    • Year and Date
      2008-01-26
  • [Presentation] Cortical glucose metabolisum in children with profound deafness - a PET study with visual activation2007

    • Author(s)
      Naito Y
    • Organizer
      6th Asia Pacific Symposium on Cochlear Implant and Related Sciences
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      20071030-20071102
  • [Presentation] シンポジウム「聴覚中枢におけるバイオメカニクス」:「高度難聴小児における聴覚言語野の発達」(招待講演)2007

    • Author(s)
      内藤泰
    • Organizer
      第17回日本耳科学会
    • Place of Presentation
      福岡
    • Year and Date
      20071018-20071020
  • [Presentation] 低年齢でNucleus Freedom人工内耳システムの両耳装用を開始した一症例2007

    • Author(s)
      眞鍋朋子、内藤泰、藤原敬三、篠原尚吾、菊地正弘、堀真也、諸頭三郎
    • Organizer
      第52回日本聴覚医学会
    • Place of Presentation
      名古屋市
    • Year and Date
      20071004-20071005
  • [Presentation] 高度難聴小児の聴覚中枢機構(招待講演)2007

    • Author(s)
      藤原敬三、内藤泰、千田道雄
    • Organizer
      日本音響学会2007年秋季研究発表会
    • Place of Presentation
      甲府市
    • Year and Date
      20070919-20070921
  • [Presentation] 言語音・楽音の中枢処理(招待講演)2007

    • Author(s)
      藤木暢也、内藤泰
    • Organizer
      日本音響学会2007年秋季研究発表会
    • Place of Presentation
      甲府市
    • Year and Date
      20070919-20070921
  • [Presentation] Brain metabolism of children with profound deafness-a visual language activation study by 18F-FDG-PET2007

    • Author(s)
      Naito Y
    • Organizer
      Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20070826-20070829
  • [Presentation] PET study of children with cochlear implant(招待講演)2007

    • Author(s)
      内藤泰
    • Organizer
      第1回ヴュルブルグ-長崎シーボルト記念シンポジウム
    • Place of Presentation
      長崎市
    • Year and Date
      20070406-20070407
  • [Book] 高度難聴(補聴器、人工内耳)severe to profound hearing loss (hearing aid, cochlear implant). 今日の治療指針

    • Author(s)
      内藤泰
    • Total Pages
      2010
    • Publisher
      株式会社医学書院、三美印刷
  • [Book] きっともっとずっと聴こう「聴く脳」大脳生理学から見た聴能. 声援隊特別勉強会きっともっとずっと聴こう聴覚障害児教育を考える講演とワークショップ報告集+講演集

    • Author(s)
      内藤泰
    • Total Pages
      2010
    • Publisher
      声援隊(難聴小児親の会)出版

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Published: 2011-06-18   Modified: 2014-08-15  

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