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2009 Fiscal Year Final Research Report

The research for fibrosis and retinal detachment in highly myopic eyes.

Research Project

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Project/Area Number 19592017
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

IKUNO Yasushi  Osaka University, 医学系研究科, 講師 (50294096)

Co-Investigator(Kenkyū-buntansha) GOMI Fumi  大阪大学, 医学系研究科, 講師 (80335364)
OSHIMA Yusuke  大阪大学, 医学系研究科, 助教 (20362717)
TANO Yasuo  大阪大学, 医学系研究科, 教授 (80093433)
Project Period (FY) 2007 – 2009
Keywords強度近視 / 網膜剥離 / 眼内線維化 / 視力障害
Research Abstract

Macular hole and retinal detachment is one of major vision-threatening problems especially in Japan, since we have many visual impairment due to high myopia. We investigated and found that epiretinal fibrosis is a main cause of macular hole and retinal detachment by way of myopic foveoschisis. Also indocyanine green dye which is used intraoperatively for staining internal limiting membrane remains long after surgery especially in axonal flow and retinal pigment epithelium.

  • Research Products

    (20 results)

All 2009 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (3 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Choroidal vascular hypofluorescence in indocyanine green angiography of high myopia2009

    • Author(s)
      Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tsujikawa M, Tano Y.
    • Journal Title

      Br J Ophthalmol 93

      Pages: 1687-90

    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab vs sub-tenon triamcinolone acetonide for choroidal neovascularization attributable to pathologic myopia2009

    • Author(s)
      Wakabayashi T, Ikuno Y, Gomi F, Hamasaki T, Tano Y.
    • Journal Title

      Am J Ophthalmol 148

      Pages: 591-596

    • Peer Reviewed
  • [Journal Article] Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography2009

    • Author(s)
      Ikuno Y, Tano Y.
    • Journal Title

      Invest Ophthalmol Vis Sci 50

      Pages: 3876-80

    • Peer Reviewed
  • [Journal Article] Presumed vascular traction-associated recurrence of retinal detachment in patients with myopic macular hole2009

    • Author(s)
      Sayanagi K, Oshima Y, Ikuno Y, Tano Y.
    • Journal Title

      Ophthalmic Surg Lasers Imaging 40

      Pages: 60-4

    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab for choroidal neovascularization attributable to pathological myopia: one-year results.2009

    • Author(s)
      Ikuno Y, Sayanagi K, Soga K, Sawa M, Tsujikawa M, Gomi F, Tano Y.
    • Journal Title

      Am J Ophthalmol 147

      Pages: 94-100

    • Peer Reviewed
  • [Journal Article] Marginal crack after intravitreal bevacizumab for myopic choroidal neovascularization2009

    • Author(s)
      Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tano Y.
    • Journal Title

      Acta Ophthalmol 87

      Pages: 460-3

    • Peer Reviewed
  • [Journal Article] トリアムシノロンからbevacizumabに治療を転換した近視性血管新生黄斑症2009

    • Author(s)
      上野千佳子, 生野恭司、田野保雄
    • Journal Title

      眼科臨床紀要

      Pages: 321-325

    • Peer Reviewed
  • [Journal Article] Lacquer crack formation and choroidal neovascularization in pathologic myopia2008

    • Author(s)
      Ikuno Y, Sayanagi K, Soga K, Sawa M, Gomi F, Tsujikawa M, Tano Y.
    • Journal Title

      Retina 28

      Pages: 1124-31

    • Peer Reviewed
  • [Journal Article] Foveal anatomical status and surgical results in vitrectomy for myopic foveoschisis2008

    • Author(s)
      Ikuno Y, Sayanagi K, Soga K, Oshima Y, Ohji M, Tano Y.
    • Journal Title

      Jpn J Ophthalmol 52(4)

      Pages: 269-76

    • Peer Reviewed
  • [Journal Article] Abnormal fundus autofluorescence patterns in myopic choroidal neovascularisation2008

    • Author(s)
      Sawa M, Gomi F, Tsujikawa M, Ikuno Y, Sakaguchi H, Sayanagi K, Tano Y.
    • Journal Title

      Br J Ophthalmol 92

      Pages: 1236-40

    • Peer Reviewed
  • [Journal Article] Fundus autofluorescence related to retinal morphological and functional changes in idiopathic macular holes2008

    • Author(s)
      Wakabayashi T, Ikuno Y, Sayanagi K, Soga K, Oshima Y, Tano Y.
    • Journal Title

      Acta Ophthalmol 86

      Pages: 897-901

    • Peer Reviewed
  • [Journal Article] Photoreceptor inner and outer segment defects in myopic foveoschisis2008

    • Author(s)
      Sayanagi K, Ikuno Y, Soga K, Tano Y.
    • Journal Title

      Am J Ophthalmol 145

      Pages: 902-8

    • Peer Reviewed
  • [Journal Article] Different fundus autofluorescence patterns of retinoschisis and macular hole retinal detachment in high myopia2007

    • Author(s)
      Sayanagi K, Ikuno Y, Tano Y.
    • Journal Title

      Am J Ophthalmol 144

      Pages: 299-301

    • Peer Reviewed
  • [Journal Article] Residual indocyanine green fluorescence pattern after vitrectomy with internal limiting membrane peeling in high myopia2007

    • Author(s)
      Sayanagi K, Ikuno Y, Soga K, Sawa M, Tano Y.
    • Journal Title

      Am J Ophthalmol 144

      Pages: 600-7

    • Peer Reviewed
  • [Presentation] Punctate Inner Choroidopathy and the Visual Outcome After Avastin for Secondary CNV2009

    • Author(s)
      Jo Y, Ikuno Y, Tano Y.
    • Organizer
      2009 American Academy of Ophthalmology Annual Meeting San Francisco
    • Place of Presentation
      U.S.A.
    • Year and Date
      2009-10-26
  • [Presentation] Postoperative Changes in Fundus Autofluorescence in Myopic Foveoschisis and Macular Hole and Retinal Detachment2007

    • Author(s)
      Sayanagi K, Ikuno Y, Tano Y.
    • Organizer
      2007 American Academy of Ophthalmology Annual Meeting
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2007-10-09
  • [Presentation] Intravitreal bevacizumab (Avastin) injection for choroidal neovascularization due to pathological myopia2007

    • Author(s)
      Ikuno Y, Sayanagi K, Tano Y.
    • Organizer
      2007 American Academy of Ophthalmology Annual Meeting
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2007-10-09
  • [Book] みんなの硝子体手術2007

    • Author(s)
      生野恭司
    • Total Pages
      227-232
    • Publisher
      文光堂
  • [Book] みんなの硝子体手術2007

    • Author(s)
      佐柳香織、生野恭司
    • Total Pages
      256-257
    • Publisher
      文光堂
  • [Patent(Industrial Property Rights)] 軸性近視の予防または治療剤2008

    • Inventor(s)
      生野恭司、田野保雄
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      特願2008-190673
    • Filing Date
      2008-07-24

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Published: 2011-06-18   Modified: 2016-04-21  

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