2009 Fiscal Year Final Research Report
Bio-physiological analysis of superior oblique palsy
| Project/Area Number |
19592023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Okayama University |
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Principal Investigator |
OTSUKI Hiroshi Okayama University, 大学院・医歯薬学総合研究科, 教授 (70093672)
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| Co-Investigator(Kenkyū-buntansha) |
KONO Reika 岡山大学, 岡山大学病院, 医員 (40301296)
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| Research Collaborator |
IMAI Sayuri 岡山大学, 大学院・医歯薬学総合研究科
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| Project Period (FY) |
2007 – 2009
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| Keywords | 上斜筋麻痺 / 遺伝子解析 / Bielschowsky頭部傾斜試験 / 静的眼球反対回旋 / MRI画像解析 |
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| Research Abstract |
The ARIX 153G>A polymorphism might be a genetic factor for the development of congenital superior oblique palsy by analyzing nucleotide changes in 3 genes, ARIX, PHOX2B, and KIF21A in congenital superior oblique palsy (SOP). By measuring static ocular counterrolling with aid of measuring system of head mounted video CCD camera, absolute value of the hypertropia on ipsilateral head tilt in clinically diagnosed SOP dose not directly assess the function in the SO muscle, the difference in hypertropia between ipsilateral head tilt and the upright position is a better indicator of SOP. SO muscle size does not account for the variation in Bielschowsky head tilt phenomenon in SOP with MRI study, supporting the proposition that the Bielschowsky head tilt phenomenon is nonspecific for SO function.
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