Genetic analysis of diabetic retinopathy and age-related macular degeneration

2008 Fiscal Year Final Research Report

• Project/Area Number: 19592037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Saitama Medical University
• Principal Investigator: AWATA Takuya Saitama Medical University, 医学部, 教授 (40184303)
• Co-Investigator(Renkei-kenkyūsha): MORI Keisuke 埼玉医科大学, 医学部, 准教授 (90251090) ; IIZUKA Hiroyuki 埼玉医科大学, 医学部, 助教 (20348246)
• Project Period (FY): 2007 – 2008
• Keywords: 疾患感受性遺伝子

Research Abstract

候補遺伝子解析により、糖尿病網膜症とPEDF遺伝子との関連、加齢黄斑変性症とCFH遺伝子およびHTRA1遺伝子との関連を日本人で初めて見出し、国際誌に報告した。また、最近になり可能となった網羅的解析であるゲノムワイド関連解析(GWAS)を糖尿病網膜症に対して開始し、二次解析終了時点で有望なSNPがいくつか見出されており、今後さらに解析を進めていく予定である。

Research Products

• [Journal Article] Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population (2007)
  • Author(s): Mori K, Gehlbach PL, Kabasawa S, Kawasaki I, Oosaki M, Iizuka H, Katayama S, Awata T, Yoneya S
  • Journal Title: Invest Ophthalmol Vis Sci 48(11) Pages: 5315-5319
  • Peer Reviewed
• [Journal Article] Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population (2007)
  • Author(s): Mori K, Horie-Inoue K, Kohda M, Kawasaki I, Gehlbach PL, Awata T, Yoneya S, Okazaki Y, Inoue S
  • Journal Title: J Hum Genet 52(7) Pages: 636-641
  • Peer Reviewed
• [Journal Article] Homozygosity haplotype allows a genomewide search for the autosomal segments shared among patients (2007)
  • Author(s): Miyazawa H, Kato M, Awata T, Kohda M, Iwasa H, Koyama N, Tanaka T, Huqun, Kyo S, Okazaki Y, Hagiwara K
  • Journal Title: Am J Hum Genet 80(6) Pages: 1090-102
  • Peer Reviewed
• [Journal Article] Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy (2007)
  • Author(s): Iizuka H, Awata T, Osaki M, Neda T, Kurihara S, Inoue K, Inukai K, Kabasawa S, Mori K, Yoneya S, Katayama S
  • Journal Title: Biochem Biophys Res Commun 361(2) Pages: 421-426
  • Peer Reviewed
• [Journal Article] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
  • Author(s): Mori K, Horie-Inoue K, Gehlbach PL, Takita H, Kabasawa S, Kawasaki I, Ohkubo T, Kurihara S, Iizuka H, Miyashita Y, Katayama S, Awata T, Yoneya S, Inoue S
  • Journal Title: Ophthalmology in press
  • Peer Reviewed
• [Presentation] 糖尿病研究の将来展望、遺伝子 (2009)
  • Author(s): 粟田卓也
  • Organizer: 第43回糖尿病学の進歩
  • Place of Presentation: 松本
  • Year and Date: 20090200
• [Presentation] 糖尿病網膜症の遺伝因子 (2008)
  • Author(s): 粟田卓也
  • Organizer: 第14回日本糖尿病眼学会
  • Place of Presentation: 東京
  • Year and Date: 20080300
• [Presentation] 網膜症糖尿病網膜症・黄斑症とPKC-β遺伝子(PRKCB1)プロモーター多型との関連 (2007)
  • Author(s): 飯塚裕幸, 粟田卓也, 根田保, 大崎昌孝, 栗原進, 井上清彰, 森圭介, 米谷新, 片山茂裕
  • Organizer: 第22回日本糖尿病合併症学会
  • Place of Presentation: 茨城
  • Year and Date: 20071000
• [Presentation] 糖尿病網膜症・黄斑症の遺伝因子 VEGF遺伝子とPEDF遺伝子 (2007)
  • Author(s): 根田保, 粟田卓也, 飯塚裕幸, 大崎昌孝, 栗原進, 井上清彰, 森圭介, 米谷新, 片山茂裕
  • Organizer: 第50回日本糖尿病学会
  • Place of Presentation: 宮城
  • Year and Date: 20070500
• [Presentation] 糖尿病網膜症・黄斑症とPEDF遺伝子との関連 (2007)
  • Author(s): 粟田卓也
  • Organizer: 第11回シンポジウム糖尿病
  • Place of Presentation: 東京
  • Year and Date: 20070400
• [Book] 糖尿病学 基礎と臨床 (2007)
  • Author(s): 粟田卓也
  • Total Pages: 265-267
  • Publisher: 西村書店