• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2008 Fiscal Year Final Research Report

Examination for detection of early glaucoma with ON- and OFF-delays of subjects with normal and glaucomatous eyes

Research Project

  • PDF
Project/Area Number 19592051
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center

Principal Investigator

WATANABE Masami  Institute for Developmental Research, Aichi Human Service Center, 周生期学部, 主任研究員 (10093486)

Co-Investigator(Kenkyū-buntansha) KONDO Mineo  名古屋大学, 大学院医学系研究科感覚器障害制御講座, 准教授 (80303642)
Co-Investigator(Renkei-kenkyūsha) SAGAWA Hiroe  豊田刈谷総合病院, 眼科, 医員
Project Period (FY) 2007 – 2008
Keywords緑内障 / 視野計 / ON中心型神経節細胞 / OFF中心型神経節細胞 / 視神経再生 / 網膜組織培養 / Unoprostone
Research Abstract

1.緑内障の早期発見を目指して従来の視野計の改良を行った。正常と緑内障の被験者に、発光ダイオードの点滅に合わせてスイッチの点滅を行ってもらったところ、点灯に反応する時間が緑内障患者で遅い傾向を示した。2.緑内障治療薬ウノプロストンの視神経再生促進作用を、網膜培養と視神経内軸索再生で調べた。濃度3μMで促進効果が最大で、神経突起のみ伸展していた。

  • Research Products

    (18 results)

All 2009 2008 2007

All Journal Article (9 results) Presentation (9 results)

  • [Journal Article] Generation of a transgenic rabbit model of retinal degeneration2009

    • Author(s)
      Kondo M, Sakai T, Komeima K, Kunmoto Y. Ueno S, Nishizawa Y, Usukura J, Tano Y, Terasaki H
    • Journal Title

      Invest. Ophthal. Vis. Sci. 50

      Pages: 1371-1377

  • [Journal Article] Differential effect of ROCK inhibitors, Fasudil and Y-27632, on promotion of optic nerve regeneration in adult cats2008

    • Author(s)
      Ichikawa M, Yoshida J, Saito K, Sagawa H, Tokita Y, Watanabe M
    • Journal Title

      Brain Res. 1021

      Pages: 23-33

  • [Journal Article] Focal macular cone ERG in complete type CSNB : A companson with APB-treated monkeys2008

    • Author(s)
      Kondo M, Piao CH, Kachi S, Miyake Y, Terasaki H
    • Journal Title

      Vision Res. 48

      Pages: 273-280

  • [Journal Article] ほ乳動物の視神経再生2008

    • Author(s)
      渡部眞三
    • Journal Title

      神経精神薬理 28

      Pages: 143-148

  • [Journal Article] Recording focal macular photopic negative response (PhNR) from monkeys2008

    • Author(s)
      Kondo M, Kurimoto Y, Sakai T, Koyasu T, Miyata K, Ueno S, Terasaki H
    • Journal Title

      Invest. Ophthal. Vis. Sci. 49

      Pages: 3544-3550

  • [Journal Article] A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinalga nglion cells into the optic nerve of adult cats2007

    • Author(s)
      Sagawa H, Terasaki H, Nakamura M, Ichikawa M, Yata T, Tokita Y, Watanabe M
    • Journal Title

      Exp. Neurol. 205

      Pages: 230-240

  • [Journal Article] Survival and axonal regeneration of OFF-center retinal ganglion cells of adult cats are promoted with an anti-glaucoma drag, nipradilol, but not BDNFand CNTF2007

    • Author(s)
      Yata T, Nakamura M, Sagawa H, Tokita Y, Terasaki H, Watanabe M
    • Journal Title

      Neuroscience 148

      Pages: 53-64

  • [Journal Article] Correlation between focal macular electroretinograms and angiographic findings after photodynamic therapy2007

    • Author(s)
      Ishikawa K. Kondo M, Ito Y, Kikuchi M, Nishihara H, Piao CH, Sugita T, Terasaki H.
    • Journal Title

      Invest. Ophthal. Vis. Sci. 48

      Pages: 2254-2259

  • [Journal Article] Preservation of macular oscillatory potentials in eyes of patients withretinitis pigmentosa and normal visual acuity2007

    • Author(s)
      Ikenoya K, Kondo M, Piao CH, Kachi S, Miyake Y, Terasaki H
    • Journal Title

      Invest. Ophthal. Vis. Sci. 48

      Pages: 3312-3317

  • [Presentation] 網膜機能解析の進歩と将来2008

    • Author(s)
      近藤峰生
    • Organizer
      シンポジウム「視覚機能の評価」第38回日本臨床神経生理学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-11-15
  • [Presentation] 網膜変性疾患の評価2008

    • Author(s)
      近藤峰生
    • Organizer
      シンポジウム「ERGによる黄斑の機能評価」第62回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-23
  • [Presentation] Recording focal macular PhNR from monkeys2008

    • Author(s)
      Kondo M, Kurimoto Y, Terasaki H
    • Organizer
      18th International Congress for Eye Research
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-09-28
  • [Presentation] Preservation of macular oscillatory potentials in eyes with retinitis pigmentosa with normal visual acuity2008

    • Author(s)
      Kondo M, Ikenoya K, Terasaki H
    • Organizer
      18th International Congress for Eye Research
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-09-28
  • [Presentation] NMDA毒性に対するネコ網膜神経節細胞のタイプによる感受性の違い : 視神経切断との比較2008

    • Author(s)
      渡部眞三, 中澤徹, 工藤英代
    • Organizer
      第12回視覚科学フォーラム
    • Place of Presentation
      大阪
    • Year and Date
      2008-08-29
  • [Presentation] Effects of two Rho inhibitors on axonal regeneration into the crushed cat optic nerve2008

    • Author(s)
      Watanabe M, Ichikawa M, Sagawa H, Tokita Y
    • Organizer
      ARVO
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      2008-05-01
  • [Presentation] 網膜再生治療に必要な動物モデルとremodeling2008

    • Author(s)
      近藤峰生
    • Organizer
      シンポジウム : 第7回日本再生医療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-14
  • [Presentation] OFF神経節細胞とON神経節細胞の生存および軸索再生能2007

    • Author(s)
      渡部眞三, 時田義人
    • Organizer
      日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-10
  • [Presentation] Survival difference in type and function of retinal ganglion cells against NMDA toxicity in adult cats2007

    • Author(s)
      Watanabe M, Kudo H, Nakazawa T, Tamai M
    • Organizer
      ARVO
    • Place of Presentation
      Fort Lauderdale
    • Year and Date
      2007-05-06

URL: 

Published: 2010-06-10   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi