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2008 Fiscal Year Final Research Report

Investigation for maintaining transplanted intestinal allograft function and for preventing respiratory tract infection by the application of a concept of gut-brain axis

Research Project

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Project/Area Number 19592064
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

KIMURA Osamu  Kyoto Prefectural University of Medicine, 医学研究科, 准教授 (10315963)

Co-Investigator(Kenkyū-buntansha) HIGUCHI Kouji  京都府立医科大学, 医学研究科, 助教 (00433251)
Project Period (FY) 2007 – 2008
Keywords小腸移植 / 神経ペプチド / 腸-脳相関 / bombesin / 感染予防 / 粘膜免疫
Research Abstract

小腸移植後の免疫抑制剤大量投与下では、移植腸管の粘膜は萎縮し、また、呼吸器感染に対する抵抗力も低下している。安全に小腸移植を行うためには、移植後の小腸の機能を正常に維持すること、また、呼吸器感染を予防することが重要である。今回の研究では腸-脳相関の概念を応用し、神経ペプチドであるbombesinを移植後に投与し、移植腸管の機能維持あるいは呼吸器感染予防が可能かを検討したところ、移植腸管の粘膜構造だけではなく、消化管運動に重要な役割を果たす神経節細胞やペースメーカー細胞であるCajal細胞もbombesinが正常と同様に維持することが判明した。呼吸器感染予防に関しては現在のところ十分なデータ解析に至っていない。

  • Research Products

    (4 results)

All 2009 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Bombesin can minimize impairments of interstitial cells of Cajal induced by FK506 in small bowel transplantation2009

    • Author(s)
      Higuchi K, Kimura O, Furukawa T, Kinoshita H, Iwai N.
    • Journal Title

      Journal of Pediatric Surgery 44

      Pages: 541-545

    • Peer Reviewed
  • [Journal Article] Management strategies for infants with total intestinal aganglionosis

    • Author(s)
      Kimura O, Ono S, Furukawa T, Higuchi K, Deguchi E, Iwai N.
    • Journal Title

      Journal of Pediatric Surgery (in press)

    • Peer Reviewed
  • [Presentation] Nutritional management of infants with total intestinal aganglionosis2008

    • Author(s)
      Osamu Kimura
    • Organizer
      41th Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Jackson Lake, USA
    • Year and Date
      2008-06-04
  • [Presentation] Bombesin can rescue the enteric ganglia from FK506 neurotoxicity on small bowel transplantation2007

    • Author(s)
      Higuchi K
    • Organizer
      Xth International Small Bowel Transplant Symposium
    • Place of Presentation
      California, USA
    • Year and Date
      2007-09-07

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Published: 2010-06-10   Modified: 2016-04-21  

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