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2009 Fiscal Year Final Research Report

Neural network analysis after the "cross-link" surgery between facial nerve and hypoglossal nerve

Research Project

  • PDF
Project/Area Number 19592075
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionKobe University

Principal Investigator

HASHIKAWA Kazunobu  Kobe University, 医学部附属病院, 助教 (90403237)

Co-Investigator(Kenkyū-buntansha) TAHARA Shinya  神戸大学, 医学部付属病院, 教授 (60207206)
TERASHIMA Toshio  神戸大学, 医学研究科, 教授 (20101892)
Project Period (FY) 2007 – 2010
Keywords再建外科学 / 顔面神経麻痺
Research Abstract

Cross-Link nerve grafting technique between facial nerve and hypoglossal nerve with grafted sensory nerve for facial nerve palsy has demonstrated effectiveness in patients. This is very interesting surgical method, though no basic research has been performed to analyze the newly formed neural circuit. We constructed the rat cross-link nerve grafted model and introduced the neural tracer method. In our experiment, anterograde labeling showed that axons of hypoglossal neuron pass through the grafted nerve and extend to facial nerve bundle. On the other hand, in retrograde labeling study, axons from facial nucleolus extend to hypoglossal nerve bundle and from hypoglossal nucleous to facial nerve bundle. These data suggest that crossing of axons are caused by the Cross-Link nerve grafting.

  • Research Products

    (10 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Facial Hypoglossal Nerve Cross-Link Surgery for Involuntary Eye Closure with Tongue Movement as a Sequela of Hunts Syndrome: A case Report.2010

    • Author(s)
      Hashikawa K, Sakakibara S, Ishida Y.
    • Journal Title

      Facial Nerve Research. 29

      Pages: 93-6

    • Peer Reviewed
  • [Journal Article] Neural circuit analysis with neural tracer on rat model of cross-link nerve grafting between facial and hypoglossal nerve.2009

    • Author(s)
      Sakakibara S, Hashikawa K, Ishida Y
    • Journal Title

      Facial Nerve Research. 28

      Pages: 8-50

    • Peer Reviewed
  • [Journal Article] 顔面-舌下神経クロスリンク型神経移植術~顔面神経麻痺に対するSurgical rehabilitationの新展開2009

    • Author(s)
      橋川和信, 田原真也
    • Journal Title

      医学のあゆみ 228

      Pages: 928-929

    • Peer Reviewed
  • [Journal Article] 順行性トレーサー法による舌下神経染色法.2008

    • Author(s)
      榊原俊介, 橋川和信, 石田泰久, 永田育子, 大守誠, 寺師浩人, 田原真也
    • Journal Title

      日本マイクロ会誌 21

      Pages: 28-32

    • Peer Reviewed
  • [Presentation] 神経トレーサー法による新しい再生神経ネットワークの解析2009

    • Author(s)
      榊原俊介
    • Organizer
      第18回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      20091001-20091002
  • [Presentation] 舌と眼瞼の異常共同運動が顔面神経-舌下神経クロスリンク手術により軽快した顔面神経不全麻痺症例の経験2009

    • Author(s)
      橋川和信
    • Organizer
      第32回日本顔面神経研究会
    • Place of Presentation
      淡路
    • Year and Date
      20090604-20090605
  • [Presentation] 顔面神経麻痺に対するsurgical and post-surgical rehabilitation~顔面-舌下神経クロスリンク手術~2009

    • Author(s)
      橋川和信
    • Organizer
      第52回日本形成外科学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20090422-20090424
  • [Presentation] 顔面-舌下神経cross-link型神経移植での順行性トレーサー法による解析2008

    • Author(s)
      榊原俊介
    • Organizer
      第51回日本形成外科学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      20080409-20080411
  • [Book] 前腕皮弁.形成外科診療プラクティス 皮弁外科・マイクロサージャリーの実際 挙上~血管吻合の基本から美容的観点を含めて2010

    • Author(s)
      橋川和信, 田原真也
    • Total Pages
      69-73
    • Publisher
      文光堂
  • [Book] 形成外科ADVANCEシリーズII-6各種局所皮弁による顔面の再建:最近の進歩2009

    • Author(s)
      橋川和信, 寺師浩人, 田原真也
    • Total Pages
      108-17
    • Publisher
      克誠堂出版

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Published: 2011-06-18   Modified: 2016-04-21  

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