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2009 Fiscal Year Final Research Report

Role of vasopressin during septic shock

Research Project

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Project/Area Number 19592087
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionGunma University

Principal Investigator

HINOHARA Hiroshi  Gunma University, 医学部, 助教 (70361376)

Co-Investigator(Kenkyū-buntansha) KADOI Yuji  群馬大学, 医学部, 准教授 (10292591)
Project Period (FY) 2007 – 2009
Keywords敗血症 / Vasopressin / 糖尿病 / 循環動態
Research Abstract

Purpose : The purpose of this study was to compare the effects of norepinephrine (NE) and vasopressin on systemic hemodynamics, renal and mesenteric artery blood flow, inflammatory response and inducible nitric oxide synthase (iNOS) activity during endotoxin shock in streptozotocin-induced diabetic rats.
Methods : The study was designed to include 3 sets of experiments : 1) measurement of changes in systemic hemodynamics and mesenteric and renal artery blood flow ; 2) measurement of biochemical variables ; and 3) measurement of iNOS activity in the mesenteric artery. Systemic hemodynamics, regional artery blood flow changes and biochemical variables were assessed before treatment and 1, 2 and 3 h after treatment.
Results : Vasopressin, but not NE, prevented the decreases in aortic blood flow, but did not restore mesenteric artery blood flow. In addition, vasopressin partially restored renal artery blood flow in diabetic rats. Plasma nitrite levels and iNOS activity in the mesenteric artery were elevated after intravenous LPS in diabetic rats. Endotoxin-induced decreases in mesenteric arterial blood flow were partially restored by vasopressin with non-selective NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), in diabetic rats. Moreover, L-NAME prevented increases in plasma nitrite levels and iNOS activity in the mesenteric artery. In contrast, endotoxin-induced decreases in renal arterial blood flow were partially restored by vasopressin with L-NAME, but not by NE in diabetic rats.
Conclusions : Nitric oxide may be one possible contributor to reduced sensitivity of the mesenteric and renal arteries to vasopressin during septic shock in streptozotocin-induced diabetic rats.

  • Research Products

    (5 results)

All 2010 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Comparison of the effects of vasopressin and norepinephrine on organ perfusion during septic shock in streptozotocin-induced diabetic rats2010

    • Author(s)
      Hinohara H, Kadoi Y, Tokue A, Saito S, Kawauchi C, Mizutani A.
    • Journal Title

      J Anesthesia. (in press)

    • Peer Reviewed
  • [Journal Article] Effects of the cannabinoid antagonist AM281 on systemic hemodynamics and mortality rate in streptozotocin-induced diabetic rats with endotoxic shock-Comparison between non-diabetic and diabetic rats2008

    • Author(s)
      Kadoi Y, Hinohara H, Kunimoto F, Saito S
    • Journal Title

      Acta Anaesthesiol.Scand. 52

      Pages: 664-672

    • Peer Reviewed
  • [Journal Article] Comparative effects of propofol versus dexmedetomidine on cerebrovascular carbon dioxide reactivity in patients with septic shock2008

    • Author(s)
      Kadoi Y, Saito S, Kawauchi C, Hinohara H, Kunimoto F
    • Journal Title

      Br.J Anesth. 100

      Pages: 224-229

    • Peer Reviewed
  • [Presentation] Pneumocystis carinii pneumonia (PCP) を疑いICUにて治療した9例の検討2010

    • Author(s)
      内藤雅仁, 国元文生, 大川牧生, 日野原宏, 大嶋清宏, 門井雄司, 吉川大輔, 斎藤繁
    • Organizer
      第37回日本集中治療医学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-05
  • [Presentation] 集中治療室入室症例におけるEAA (Endotoxin Activity Assay) 測定の意義-感染症症例に関する検討-2010

    • Author(s)
      大嶋清宏, 国元文生, 日野原宏, 大川牧生, 門井雄司, 斎藤繁
    • Organizer
      第37回日本集中治療医学会総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-05

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Published: 2011-06-18   Modified: 2016-04-21  

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