Evaluation of risk factors and early diagnosis of sepsis.

2009 Fiscal Year Final Research Report

• Project/Area Number: 19592089
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Nagoya University
• Principal Investigator: MAYUMI Toshihiko Nagoya University, 医学部附属病院, 講師 (90281071)
• Co-Investigator(Kenkyū-buntansha): ARISHIMA Takuro 富山大学, 医学部, 准教授 (20335045)
• Project Period (FY): 2007 – 2009
• Keywords: 敗血症 / リスク因子 / 遺伝子多型 / 診断 / エンドトキシン / antithrombin活性 / disseminated intravascular coagulation (DIC)

Research Abstract

Since even now, sepsis is still high mortality, control of sepsis is an important strategy. In this study, we elucidated the prognostic predictor of sepsis, severe sepsis, and septic shock. We started multicenter study to analyze the genetic polymorphism of the patients of septic patients in the ICU and their relations to the prognosis.
Also, we antithrombin (AT) activity after AT administration and the rate of increase of the AT activity value after the AT administration were significantly higher in survived septic DIC patients than those fatal patients. Therefore, it was suggested that the prognostic value by AT activity and its change before and after AT administration.

Research Products

• [Journal Article] Expert consensus for the treatment of disseminated intravascular coagulation in Japan. (2010)
  • Author(s): Wada H, Asakura H, Okamoto K, Iba T, Uchiyama T, Kawasugi K, Koga S, Mayumi T, Koike K, Gando S, Kushimoto S, Seki Y, Madoiwa S, Maruyama I, Yoshioka A
  • Journal Title: Thromb Res(Japanese Society of Thrombosis Hemostasis/DIC subcommittee.) 125 Pages: 6-11
  • Peer Reviewed
• [Journal Article] 重症セプシス治療に関する本邦の現状と国際的ガイドラインとの比較. (2010)
  • Author(s): 射場敏明、真弓俊彦、小倉真治、石倉宏恭、小谷穣治、松田直之、横田裕行
  • Journal Title: 日本救急医学会雑誌 20 Pages: 913-922
  • Peer Reviewed
• [Journal Article] Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. Disseminated intravascular coagulation (DIC) diagnosed based on the Japanese Association for Acute Medicine criteria is a dependent continuum to overt DJapanese Association for Ac (2009)
  • Author(s): Gando S, Saitoh D, Ogura H, Mayumi T, Koseki K, Ikeda T, Ishikura H, Iba T, Ueyama M, Eguchi Y, Otomo Y, Okamoto K, Kushimoto S, Endo S, Shimazaki S
  • Journal Title: Thrombosis Research 123 Pages: 715-718
  • Peer Reviewed
• [Journal Article] 敗血症診療の現在-SSCG2008とその後-SSCG2008とその後の展開について5. DIC治療. (2009)
  • Author(s): 真弓俊彦、鈴木秀一、都築通孝、小野寺睦雄、有嶋拓郎、高橋英夫
  • Journal Title: Progress in Medicine 129 Pages: 1505-1510
• [Journal Article] 重症セプシス治療に関するエビデンスの不確実性. (2009)
  • Author(s): 射場敏明、真弓俊彦
  • Journal Title: 日本集中治療学会誌 16 Pages: 255-262
  • Peer Reviewed
• [Journal Article] 敗血症での診療手順と必要な手技は? (2009)
  • Author(s): 真弓俊彦
  • Journal Title: レジデントノート 11 Pages: 1122-1129
• [Journal Article] ATIII値の重要性とエキスパートコンセンサスにおけるAT製剤の位置づけ. (2009)
  • Author(s): 真弓俊彦
  • Journal Title: Coagulation & Infl ammation 3 Pages: 13-18
• [Journal Article] 科学的根拠に基づいた感染症に伴うDIC治療のエキスパートコンセンサス. (2009)
  • Author(s): 丸山征郎、坂田洋一、和田英夫、朝倉英策、岡島研二、丸藤哲、射場敏明、内場光浩、内山俊正、江口豊、岡本好司、小倉真治、川杉和夫、久志本成樹、小池薫古賀震、関義信、窓岩清治、真弓俊彦
  • Journal Title: 日本血栓止血学会誌 20 Pages: 77-113
  • Peer Reviewed
• [Journal Article] Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: Results of a multicenter, prospective survey. (2008)
  • Author(s): Gando S, Saitoh D, Ogura H, Mayumi T, (他11名、4番目).
  • Journal Title: Crit Car Med 36 Pages: 145-150
  • Peer Reviewed
• [Journal Article] Clinical course and outcome of disseminated intravascular coagulation diagnosed by Japanese Association for Acute Medicine criteria. (2008)
  • Author(s): Kushimoto S, Gando S, Saitoh D, Mayumi T, (他11名、5番目)
  • Journal Title: Thromb Haemost 100 Pages: 099-1105
  • Peer Reviewed
• [Journal Article] SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. (2007)
  • Author(s): Ogura H, Gando S, Iba T, Ohtomo Y, Mayumi T, (他11名、8番目)
  • Journal Title: Shock 28 Pages: 411-417
  • Peer Reviewed
• [Journal Article] Predicting the severity of systemic inflammatory response syndrome (SIRS)-associated coagulopathy with hemostatic molecular markers and vascular endothelial injury markers. Preview. (2007)
  • Author(s): Iba T, Gando S, Murata A, Kushimoto S, Mayumi T, (他11名、10番目)
  • Journal Title: J Trauma 63 Pages: 1093-1098
  • Peer Reviewed
• [Presentation] 敗血症におけるトロンボモジュリンの投与前後のアンチトロンビン活性値の変化. (2010)
  • Author(s): 小野寺睦雄、鈴木秀一、都築通孝、金碧年、井上卓也、真弓俊彦、貝沼関志、高橋英夫
  • Organizer: 第37回日本集中治療医学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-05
• [Presentation] 日本救急医学会Sepsis Registry((JAAM-SR):米国Surviving Sepsis Campaign (SSC)データベース(DB)への参加と日本独自のデータ収集. (2010)
  • Author(s): 藤島清太郎、丸藤哲、鈴木幸一郎、齋藤大蔵、真弓俊彦、田熊清継、荒木恒敏、池田弘人、小倉裕司、久志本成樹、小谷穣治、鈴木泰、武山直志、鶴田良介、山下典雄、相川直樹、山口芳裕
  • Organizer: 第37回日本集中治療医学会学術集会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-05
• [Presentation] 遺伝子多型と外科感染症. (2009)
  • Author(s): 真弓俊彦
  • Organizer: 第22回日本外科感染症学会学術集会教育講演
  • Place of Presentation: 宇部
  • Year and Date: 2009-12-10
• [Presentation] 敗血症性凝固異常におけるATIII活性、ATII製剤投与の意義. (2009)
  • Author(s): 真弓俊彦、鈴木秀一、都築通孝、小野寺睦雄、有嶋拓郎、高橋英夫
  • Organizer: 第36回日本集中治療医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-26
• [Presentation] 敗血症におけるATIII活性、ATIII製剤投与の意義. (2008)
  • Author(s): 真弓俊彦、鈴木秀一、都築通孝、小野寺睦雄、有嶋拓郎、高橋英夫
  • Organizer: 第21回日本外科感染症学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2008-11-07
• [Presentation] 日本救急医学会DIC特別委員会. SIRS-associated coagulopathy(SAC)病態と転帰予測因子. (2007)
  • Author(s): 小倉裕司、小関一英, 大友康裕, 齋藤大蔵, 岡本好司, 真弓俊彦, 射場敏明, 江口豊, 池田寿昭, 石倉宏泰, 上山昌史, 久志本成樹, 遠藤重厚, 島崎修次, 丸藤哲
  • Organizer: 第30回日本血栓止血学会学術集会
  • Place of Presentation: 三重県志摩
  • Year and Date: 2007-11-16