2010 Fiscal Year Final Research Report
Effects of atropine and oximes on neuronal actions of organophospholus cholinesterase inhibitors.
| Project/Area Number |
19592093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
NARIMATSU Eichi Sapporo Medical University, 医学部, 准教授 (70295343)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMATA Mikito 信州大学, 医学部, 教授 (90315523)
KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388)
NIIYA Tomohisa 札幌医科大学, 医学部, 助教 (80510312)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 海馬 / 伝達 / 有機リン剤 / オキシム剤 / アトロピン |
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| Research Abstract |
We investigated influences of paraoxon (an organophospholus cholinesterase inhibitor), atropine and pralidoxime (an oxime) on glutamatergic excitatory synaptic transmission and neuronal somatic excitability using rat hippocampal slices. Paraoxon depressed the excitatory synaptic transmission and facilitates the excitability. Pralidoxime and atropine prevent and depress the actions of paraoxon and are more effective with earlier treatment.
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