The effect of exercise training on circulatory shock with special reference on hepatic circulation

2008 Fiscal Year Final Research Report

• Project/Area Number: 19592103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: MIYAMAE Shunichi Kanazawa Medical University, 医学部, 講師 (30121263)
• Co-Investigator(Kenkyū-buntansha): SHIBAMOTO Toshishige 金沢医科大学, 医学部, 教授 (90178921)
• Project Period (FY): 2007 – 2008
• Keywords: 救急蘇生学 / 循環ショック

Research Abstract

運動トレーニングがアナフィラキシーショック、敗血症によるショックのモデルであるエンドトキシンショック、出血性ショックを軽減できるかどうか、ラット実験モデルで検討した。運動はトレッドミルで、速度10m/min、持続10分間から30m/min、30分間まで4週かけて漸増し負荷した。運動トレーニングはアナフィラキシー肝血管収縮を抑制したがアナフィラキシー低血圧は抑制しなかった。エンドトキシンショック、出血性ショックでは抑制効果はみられかった。

Research Products

• [Journal Article] Hepatic microvascular pressure during anaphylactic shock in anesthetized rats (2009)
  • Author(s): Takano H, Shibamoto T, Zhang W, Kurata Y, Toga H.
  • Journal Title: Microvasc. Res 78(2) Pages: 169-173
  • Peer Reviewed
• [Journal Article] 7-nitroindazole, but not L-name or aminoguanidine, attenuates anaphylactic hypotension in conscious rats (2009)
  • Author(s): Zhang W, Shibamoto T, Cui S, Takano H, Kurata Y.
  • Journal Title: Shock 31(2) Pages: 201-6
  • Peer Reviewed
• [Journal Article] The roles of mast cells and Kupffer cells in rat systemic anaphylaxis (2007)
  • Author(s): Shibamoto T, Shimo T, Cui S, Zhang W, Takano H, Kurata Y, Tsuchida H.
  • Journal Title: Am. J. Physiol. Regul. Integr. Comp. Physiol. 293(6) Pages: R2202-9
  • Peer Reviewed
• [Journal Article] Exercise training attenuates anaphylactic venoconstriction in perfused rat livers, but does not affect anaphylactic hypotension in conscious rats.
  • Author(s): Cui S, Shibamoto T, Zhang W, Kurata Y, Kashimura O, Miyamae S.
  • Journal Title: Clin. Exp. Pharmacol. Physiol. (in press)
• [Journal Article] Liver volume, as assessed by four ultrasonic crystals arranged to form a tetrahedron, decreases during anaphylactic shock in anesthetized rats
  • Author(s): Takano H, Shibamoto T, Zhang W, Kurata Y.
  • Journal Title: Shock (in press)
  • Peer Reviewed
• [Presentation] 運動トレーニングのラットアナフィラキシーショックへ及ぼす影響 (2009)
  • Author(s): 張偉, 芝本利重, 宮前俊一, 倉田康孝
  • Organizer: 第56回中部日本生理学会
  • Place of Presentation: 石川県金沢市
  • Year and Date: 2009-12-04
• [Presentation] The role of nitric oxide in anaphylactic shock in conscious rats (2008)
  • Author(s): Wei Zhang, Toshishige Shibamoto, Sen Cui, Hiromichi Takano, Yasutaka Kurata
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京都新宿
  • Year and Date: 2008-03-27