Study for mechanism of orofacial neuropathic pain

2008 Fiscal Year Final Research Report

• Project/Area Number: 19592108
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: TAKEMURA Motohide Osaka University, 大学院・歯学研究科, 准教授 (70192169)
• Co-Investigator(Kenkyū-buntansha): YONEHARA Norifumi 奥羽大学, 薬学部, 教授 (70124534) ; KOBAYASHI Masayuki 日本大学, 大学院・歯学研究科, 准教授 (00300830) ; SUGIYO Shinichi 大阪大学, 大学院・歯学研究科, 助教 (90397688)
• Project Period (FY): 2007 – 2008
• Keywords: 神経因性疼痛

Research Abstract

神経損傷ラットの情報伝達機構が大きく変化することが、神経因性疼痛発現の基礎にあることが明らかになった。ぺプチド性C線維を介したシグナリングが侵害刺激をよりシャープに上位中枢に送るが、非ぺプチド性C線維のシグナリングがそのぺプチド性C線維を抑制するといった制御に関わっている可能性を示すデーターを得た

Research Products

• [Journal Article] Functional organization of the rodent parabrachial nucleus (2009)
  • Author(s): Yamamoto T, Takemura M, Inui T, Torii K, Maeda N, Ohmoto Makoto, Matsumoto I,Abe K
  • Journal Title: Annals of New York Acad Science (in press)
  • Peer Reviewed
• [Journal Article] Effects of systemic bicuculline or morphine on formalin-evoked pain-relatedbehaviour and c-Fos expression intrigeminal nuclei after formalininjection into the lip or tongue in rats (2009)
  • Author(s): Sugiyo S, Uehashi D, Satoh F, Abe T, Yonehara N, Kobayashi M, Takemura M
  • Journal Title: Exp Brain Res 196 Pages: 229-237
  • Peer Reviewed
• [Journal Article] Luminal hydrogen sulfide plays a pronociceptiverole in mouse colon (2009)
  • Author(s): Matsunami M, Tarui T, Mitani K, Nagasawa K, Fukushima O, Okubo K, YoshidaS, Takemura M, Kawabata A
  • Journal Title: Gut 58 Pages: 751-761
  • Peer Reviewed
• [Journal Article] Capsaicin-induced glutamate release is implicated in nociceptive processingthrough activation of ionotropicglutamate receptors and group Imetabotropic glutamate receptor inprimary afferent fibers (2009)
  • Author(s): Jin Y-H, Yamaki F, Takemura M, Koike Yuichi, Furuyama A, Yonehara N
  • Journal Title: J Pharmacol Sci 109 Pages: 233-241
  • Peer Reviewed
• [Presentation] (2008) Intra cisterna magna and rostral ventromedial medullainjection of anti-serotonintransporter-saporin bidirectionallychanged formalin-induced pain relatedbehaviour and c-Fos expression in themedullary dorsal horn in rats (2008)
  • Author(s): Sugiyo S., Uehashi D., Masawaki A., Ohyamaguchi A., Abe T., Yonehara N.,Takemura M.
  • Organizer: Annual meetings of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-17
• [Presentation] Nociceptive behavioral responses c-Fosand pERK expression in neonatallycapsaicin-pretreated rat (2008)
  • Author(s): Uehashi D., Sugiyo S., Masawaki A., Ohyamaguchi A., Abe T., Takemura M.
  • Organizer: meetings of Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2008-11-17
• [Presentation] Neurokinin-1-receptor bearing neurons inthe trigeminal caudal nucleus are crucialfor intensity-dependent bidirectionalsensory processing through GABAAreceptors. (2008)
  • Author(s): Abe T., Takemura M., Sugiyo S., Ohyamaguchi A., Masawaki A., HasegawaM.,Honda K., Urade M.
  • Organizer: Federation of European Neurosciences Societies Forum
  • Place of Presentation: Geneva
  • Year and Date: 2008-07-13
• [Presentation] Elimination of IB4-positive trigeminalganglion neurons decreased nociceptiveresponses of the formalin-inducedpain-related behavior at first phase inthe upper lip and c-Fos expression in thetrigeminal caudal nucleus in rats (2008)
  • Author(s): Ohyamaguchi A., Sugiyo S., Abe T., Masawaki A., Niwa H., Takemura M.
  • Organizer: Federation of European Neurosciences Societies Forum
  • Place of Presentation: Geneva
  • Year and Date: 2008-07-13
• [Presentation] NK-1 receptor-bearing neurons are essentialfor systemic bicuculline- inducedantinociception in formalin test (2008)
  • Author(s): Masawaki A., Sugiyo S., Ohyamaguchi A., Abe T., Niwa H., Takemura M. (2008) NK-1receptor-bearing neurons are essentialfor systemic bicuculline- inducedantinociception in formalin test
  • Organizer: Federation of European Neurosciences Societies Forum
  • Place of Presentation: Geneva
  • Year and Date: 2008-07-13
• [Presentation] Effects of systemic bicuculline on the formalin-induced nociceptiveresponse in the lip and c-Fos expressionin the SP-Saporin-treated rats (2007)
  • Author(s): A Masawaki, S Sugiyo, T Shimoda, Y Sakai, A Ohyamaguchi, D Uehashi, MMoritani, A Yoshida, H Niwa, M Takemura
  • Organizer: 37th annual meeting of the Society forNeuroscience
  • Place of Presentation: San Diego
  • Year and Date: 20071103-07
• [Presentation] Intra cisterna magna injection of pertussistoxin enhanced mechanical nociceptiveresponses and noxiousstimulation-induced pERK expression in the trigeminal nucleus caudalis (2007)
  • Author(s): S Sugiyo, Y Sakai, T Shimoda, A Masawaki, A Ohyamaguchi, D Uehashi, MMoritani, M Takemura
  • Organizer: 37th annual meeting of the Society forNeuroscience
  • Place of Presentation: San Diego
  • Year and Date: 20071103-07
• [Presentation] Changes in sensitivity of glutamate receptors atthe peripheral endings of the nociceptivefivers following nerve injury (2007)
  • Author(s): F Yamaki, A Furuyama, M Takemura, Yuichi Koike, N Yonehara
  • Organizer: 30th Annual Meeting of Japan NeuroscienceSociety
  • Place of Presentation: Pacifico Yokohama
  • Year and Date: 2007-09-10
• [Book] (2008)口腔顔面の痛みのトピックス : 生命歯科医学のカッティング・エッジ(米田俊之編)COEモノグラフ (2008)
  • Author(s): 竹村元秀、杉生真一
  • Total Pages: 244-254
  • Publisher: 大阪大学出版会