2009 Fiscal Year Final Research Report
Study on Pathogenesis of Oro-facial Neuropathic Pain Following Peripheral Nerve Injury
| Project/Area Number |
19592111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
SUGIMOTO Tomosada Okayama University, 大学院・医歯薬学総合研究科, 教授 (50135729)
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIKAWA Hiroyuki 東北大学, 大学院・歯学部研究科, 教授 (20193435)
TERAYAMA Ryuji 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60333689)
YAMAAI Yuichiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00158057)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 神経切断 / 三叉神経 / 神経因性疼痛 / カスパーゼ / カプサイシン / ニューロン |
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| Research Abstract |
Both peripheral nerve section and systemic capsaicin treatment in newborn rats cause caspase-mediated apoptosis of injured peripheral sensory neurons. Nerve growth factor-deprivation appears to underlie the phenomenon. In adult rats the injury does not induce the neuronal death, and the surviving neurons appear to contribute to the post-traumatic neuropathic pain by excessive pain signal transmission.
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