2009 Fiscal Year Final Research Report
A study on the cooperative regulation of bone metabolism between upper and lower jaw through the trigeminal ganglion
| Project/Area Number |
19592124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
GOTO Tetsuya Kyushu Dental College, 歯学部, 准教授 (70253458)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Shigeru 九州歯科大学, 歯学部, 教授 (10118078)
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| Co-Investigator(Renkei-kenkyūsha) |
MAKI Kenshi 九州歯科大学, 歯学部, 教授 (60209400)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 神経ペプチド / 知覚神経 / 三叉神経節 / 骨芽細胞 / 破骨細胞 / 顎骨 |
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| Research Abstract |
For studying the cooperative regulation of bone metabolism between upper and lower jaw through the trigeminal ganglion, we examined the regulation system by using the cultured osteoblasts and the orthodontic tooth movement model for the rat upper molar. Our results demonstrated that the neurons for mandibular and maxilla secret the neuropeptides, such as substance P and neurokinin B, to regulate their bone metabolism through the activation of satellite cells around the neurons.
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