2009 Fiscal Year Final Research Report
Study of a novel protein secretion system of Porphyromonas gingivalis
| Project/Area Number |
19592135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SAIKI Keitarou The Nippon Dental University, 生命歯学部, 講師 (30297973)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 口腔細菌学 |
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| Research Abstract |
A novel outer membrane protein Sov and a novel membrane protein PG27 were identified as essential factors for the secretion of gingipain protease virulence factors of Porphyromonas gingivalis. The C-terminal portion of Sov is exposed to the extracellular milieu and involved in the modulation of Sov function. These results suggest that gingipains are secreted via a novel protein secretion pathway, and that Sov and PG27 are promising targets for antiperiodontitis drug development.
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