2009 Fiscal Year Final Research Report
The application of functional elucidation in epithelial-mesenchymal interaction to the practical treatment in chronic periodontitis
| Project/Area Number |
19592167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
SHIMONISHI Mitsuru Tohoku University, 病院, 助教 (40302153)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 免疫 / 感染 / 炎症 / マラッセの上皮遺残 |
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| Research Abstract |
The tissues were sampled from the root of human extracted teeth and produced outgrowths containing both epithelial cells and fibroblasts from human periodontal ligaments (HPDL). Type IV collagen were found at the interface between cells of the epithelial rests of Malassez (ERM cells) and HPDL fibroblasts. MMP-2 can degrade type IV collagen. The current study was undertaken to examine the expression of MMP-2 at the interface. These findings indicate that the ERM cells stimulate the production of MMP-2 in HPDL fibroblasts. Up-regulated MMP-2 activated by MMP-14 in ERM cells could degrade matrix molecules, such as Type IV collagen in the basal membrane between ERM cells and HPDL fibroblasts. We believe that these results are applied to the practical treatment in chronic periodontitis.
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