Development of pathogenesis based therapy for xerostomia

2009 Fiscal Year Final Research Report

• Project/Area Number: 19592177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Kyushu Dental College
• Principal Investigator: TANAKA Tatsurou Kyushu Dental College, 歯学部, 講師 (50326469)
• Project Period (FY): 2007 – 2009
• Keywords: 口腔乾燥症 / MRI / sialography / 唾液腺 / 機能 / 治療

Research Abstract

We reported the functional differences between the parotid and submandibular glands in the healthy volunteer using dynamic MR sialography. In addition, Differences between the parameters of dynamic MR sialography were elucidated between the healthy volunteer and the patient with dry mouth as chief complaint. The maximum area of the detectable ducts in the patient group was significantly smaller, while the change in detectable duct area was significantly lower. In other words, our study suggests that dynamic MR sialographic images and data can be useful in the diagnosis of patients with dry mouth as chief complaint.

Research Products

• [Journal Article] Small salivary gland size in patients with xerostomia of unknown etiology. (2009)
  • Author(s): Ono K, Tanaka T, Inoue H, Ansai T, Wakasugi-Sato, Muraoka K, Yokota M, Takehara T, Morimoto Y, Inenaga K.
  • Journal Title: Arch Oral Biol 54 Pages: 369-73
  • Peer Reviewed
• [Journal Article] Relationship between the curative effects of carbamazepine administration and the neurovascular compression volume of the trigeminal nerve measured using magnetic resonance cisternography. (2009)
  • Author(s): Tanaka T, Sakamoto E, Shiiba S, Oda M, Kito S, Wakasugi-Sato N, Matsumoto-Takeda S, Imamura Y, Nakanishi O, Morimoto Y.
  • Journal Title: Clin J Pain 25 Pages: 752-9
  • Peer Reviewed
• [Journal Article] Importance of clinical features and CT findings in numb chin syndrome: report of two cases. (2009)
  • Author(s): Yoshioka I, Shiiba S, Tanaka T, Nishikawa T, Sakamoto E, Kito S, Oda M, Wakasugi-Sato N, Matsumoto-Takeda S, Kagawa S, Nakanishi O, Tominaga K, Morimoto Y.
  • Journal Title: J Am Dent Assoc 140 Pages: 550-4
  • Peer Reviewed
• [Journal Article] Usefulness of CT scan images for planning thebone cut for Intra-oralVertical Ramus Osteotomy. (2008)
  • Author(s): Yoshioka I, Tanaka T, Oda M, Kodama M, Habu M, Kito S, Okabe S, Wakasugi-Sato N, Kuroiwa H, Tominaga K, Morimoto Y.
  • Journal Title: Journal of Maxillofacial & Oral Surgery 7 Pages: 245-250
  • Peer Reviewed
• [Journal Article] Assessment of the relationship between the mandibular cortex on panoramic radiographs and the risk of bone fracture and vascular disease in 80-year-olds (2008)
  • Author(s): Okabe S, Morimoto Y, Ansai T, Yoshioka I, Tanaka T, Taguchi A, Kito S, Wakasugi-Sato N, Oda M, Kuroiwa H, Ohba T, Awano S, Takata Y, Takehara T.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106 Pages: 433-42
  • Peer Reviewed
• [Journal Article] Dynamic magnetic resonance sialography for patients with xerostomia. (2008)
  • Author(s): Tanaka T, Ono K, Ansai T, Yoshioka I, Habu M, Tomoyose T, Yamashita Y, Nishida I, Oda M, Kuroiwa H, Wakasugi-Sato N, Okabe S, Kito S, Takahashi T, Tominaga K, Inenaga K, Morimoto Y.
  • Journal Title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106 Pages: 115-23
  • Peer Reviewed
• [Journal Article] Relationship between cortical bone formation on mandibular condyles and alternation of the magnetic resonance signals characteristic during growth. (2007)
  • Author(s): Morimoto Y, Konoo T, Tominaga K, Tanaka T, Yamaguchi K, Fukuda J, Ohba T.
  • Journal Title: Am J Orthod Dentofacial Orthop. 131 Pages: 473-80
  • Peer Reviewed
• [Journal Article] Relationship of chewing-stimulated whole saliva flow rate and salivary gland size. (2007)
  • Author(s): Ono K, Inoue H, Masuda W, Morimoto Y, Tanaka T, Yokota M, Inenaga K.
  • Journal Title: Arch Oral Biol. 52 Pages: 427-431
  • Peer Reviewed
• [Journal Article] Functional evaluations of the parotid and submandibular glands using dynamic MR sialography. (2007)
  • Author(s): Tanaka T, Ono K, Habu M, Inoue H, Tominaga K, Okabe S, Kito S, Yokota M, Fukuda J, Inenaga K, Morimoto Y.
  • Journal Title: Dentomaxillofac Radiol 36 Pages: 218-223
  • Peer Reviewed
• [Journal Article] Changes in temporomandibular disc position during growth in young Japanese. (2007)
  • Author(s): Tominaga K, Konoo T, Morimoto Y, Tanaka T, Habu M, Fukuda J.
  • Journal Title: Dentomaxillofac Radiol 36 Pages: 397-401
  • Peer Reviewed
• [Journal Article] Intraoperative surgical clearance confirmation of tongue carcinomas using ultrasound. (2007)
  • Author(s): Tominaga K, Yamamoto K, Khanal A, Morimoto Y, Tanaka T, Kodama M, Fukuda J.
  • Journal Title: Dentomaxillofac Radiol 36 Pages: 409-411
  • Peer Reviewed
• [Journal Article] Dynamic MR sialographyを用いた唾液腺の機能評価 (2007)
  • Author(s): 田中達朗、若杉奈緒、岡部幸子、鬼頭慎司、森本泰宏
  • Journal Title: 北九医工誌 16 Pages: 23-26
  • Peer Reviewed
• [Journal Article] Dynamic MR sialography for patients with Sjogren syndrome.
  • Author(s): Tanaka T, Yoshioka I, Kagawa S, Oda M, Wakasugi-Sato N, Matsumoto S, Kito S, Morimoto Y.
  • Journal Title: The 7th Asian Congress of Oral and Maxillo-Facial Radiology, Nara 20081100
• [Presentation] 口腔乾燥症患者に対するDynamic MR sialographyの有用性 (2009)
  • Author(s): 田中達朗, 鬼頭慎司, 若杉奈緒, 松本忍, 小田昌史, 内田朱美, 広松辰巳, 森本泰宏
  • Organizer: 日本歯科放射線学会第14回臨床画像大会
  • Place of Presentation: 北海道大学
  • Year and Date: 2009-10-24
• [Presentation] Dynamic MR sialography for patients with Sjogren syndrome. (2008)
  • Author(s): Tanaka T, Yoshioka I, Kagawa S, Oda M, Wakasugi-Sato N, Matsumoto S, Kito S, Morimoto Y.
  • Organizer: The 7th Asian Congress of Oral and Maxillo-Facial Radiology, Nara
  • Year and Date: 20081100
• [Presentation] シェーグレン症候群患者に対するDynamic MR sialographyの有用性 (2008)
  • Author(s): 田中達朗, 小田昌史, 若杉奈緒, 松本忍, 鬼頭慎司, 森本泰宏
  • Organizer: 日本歯科放射線学会第49回学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 20080500
• [Presentation] 口腔乾燥症治療(唾液腺洗浄法)の効果予測におけるDynamic MR sialographyの可能性 (2008)
  • Author(s): 森本泰宏, 土生学, 友寄泰樹, 吉岡泉, 尾崎由衛, 小野堅太郎, 田中達朗, 冨永和宏, 安細敏弘, 柿木保明, 高橋哲, 稲永清敏
  • Organizer: 第68回九州歯科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20080500
• [Presentation] MR sialographyを用いた唾液腺機能の評価 (2007)
  • Author(s): 田中達朗, 若杉奈緒, 小田昌史, 岡部幸子, 鬼頭慎司, 森本泰宏
  • Organizer: 第12回臨床画像大会
  • Place of Presentation: 柏
  • Year and Date: 20071000
• [Presentation] Alteration of the magnetic resonance imaging signals characteristic of mandibular condyles in growing children. (2007)
  • Author(s): Tanaka T, Okabe S, Yoshioka I, Tominaga K, Konoo T, Kito S, Morimoto Y
  • Organizer: 16th IADMFR, Beijing, China
  • Year and Date: 20070600
• [Presentation] Functional evaluation of parotid glands using dynamic MR sialography with citric acid stimulation (2007)
  • Author(s): Morimoto Y, Okabe S, Yoshioka I, Ono K, Tanaka T, Kito S, Inenaga K
  • Organizer: The 16th International Congress of Dentomaxillofacial Radiology, Beijing, China
  • Year and Date: 20070600
• [Presentation] 成長期顎関節のMRI所見の変化. (2007)
  • Author(s): 田中達朗, 岡部幸子, 鬼頭慎司, 森本泰宏
  • Organizer: 第48回日本歯科放射線学会総会・学術大会
  • Place of Presentation: 大宮
  • Year and Date: 20070500
• [Presentation] 正常ボランティアにおけるDynamic MR sialography (2007)
  • Author(s): 岡部幸子, 田中達朗, 鬼頭慎司, 森本泰宏
  • Organizer: 第48回日本歯科放射線学会総会・学術大会
  • Place of Presentation: 大宮
  • Year and Date: 20070500
• [Presentation] 排泄機能を指標にした唾液腺病変の診断に対する新たなアプローチ (2007)
  • Author(s): 森本泰宏, 小野堅太郎, 田中達朗, 冨永和宏, 安細敏弘, 柿木保明, 高橋哲, 稲永清敏
  • Organizer: 第67回九州歯科学会総会
  • Place of Presentation: 北九州
  • Year and Date: 20070500
• [Book] Double contour-like structures", characteristic magnetic resonance signals on mandibular condyles seen during child growth. (2009)
  • Author(s): Tanaka T, Konoo T, Yoshioka I, Habu M, Kito S, Kodama M, Oda M, Wakasugi-Sato N, Matsumoto S, Kagawa S, Terashita M, Tominaga K, Morimoto Y
  • Total Pages: 15-22
  • Publisher: In RESEARCH ADVANCES IN ORAL DISEASES
• [Remarks]
  • URL: http://www2.kyu-dent.ac.jp/depart/radiology/study.html