2010 Fiscal Year Final Research Report
Reduction of radiation damages on salivary glands by the aminothiols.
| Project/Area Number |
19592184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
NASU Masanori The Nippon Dental University, 生命歯学部, 准教授 (50130688)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUHASHI Fusako 日本歯科大学, 生命歯学部, 助教 (60187896)
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| Project Period (FY) |
2007 – 2010
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| Keywords | amifostine / 放射線防護 / 唾液腺 / 血管内皮細胞 |
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| Research Abstract |
Xerostomia is one of the most common complications during and after radiation therapy for head and neck cancer, because irreparable damage is caused to the salivary glands, which are included in the radiation fields. In order to prevent of the damage, the radioprotect drug, amifostine, is clinically used in USA.
.we have examined the effect of amifostine from the secretory ability of mice salivary gland acinar cells before radiation. We confirmed that the damage of the acinar cells of mice salivary glands were inhibited by amifostine during radiation compared to nonamifostine treated.
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