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2009 Fiscal Year Final Research Report

Effects of macrolides on Porphyromonas gingivalis biofolms

Research Project

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Project/Area Number 19592198
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

UEDA Mio  Osaka University, 歯学部附属病院, 医員 (90423136)

Co-Investigator(Kenkyū-buntansha) NOIRI Yuichiro  大阪大学, 歯学部附属病院, 講師 (50218286)
EBISU Shigeyuki  大阪大学, 大学院・歯学研究科, 教授 (50116000)
YOSHITAKE Fumio  大阪大学, 歯学部附属病院, 医員 (10452450)
ASAHI Yoko  大阪大学, 歯学部附属病院, 医員 (50456943)
Research Collaborator MAEZONO Hazuki  大阪大学, 大学院・歯学研究科
YAMAGUCHI Mikiyo  大阪大学, 歯学部附属病院, 医員 (30523089)
Project Period (FY) 2007 – 2009
Keywords歯学 / 歯内療法学 / 細菌 / バイオフィルム / 歯周炎
Research Abstract

The effect of azithromycin (AZM) and erythromycin (EM), which were macrolides, on Porphyromonas gingivalis biofilms produced by both static and flow-cell model was evaluated, and was compared with it against other antibiotics. AZM inhibited significantly both two biofilms in comparison with the other medicines at sub-minimum inhibitory concentration. It was guessed that the mechanism influenced three-dimensional structure or the signal transmission in the biofilm, but not was bactericidal namely an antibacterial action. And it was shown that its effect caused by the anti-biofilm action of AZM.

  • Research Products

    (13 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] 各種抗菌剤がPorphyromonas gingivalisの形成するバイオフィルムに及ぼす影響2009

    • Author(s)
      前薗葉月, 野杁由一郎, 朝日陽子, 山口幹代, 山本れいこ, 薮根敏晃, 上田未央, 恵比須繁之
    • Journal Title

      Bacterial Adherence & Biofilm 23(in press)

  • [Journal Article] Effects of N-acyl homoserine lactone analogues on Porphyromonas gingivalis biofilm formation2009

    • Author(s)
      Asahi Y, Noiri Y, Igarashi J, Asai H, Suga H, Ebisu S
    • Journal Title

      J Periodont Res 44(in press)

    • Peer Reviewed
  • [Journal Article] 口腔バイオフィルム対策2008

    • Author(s)
      野杁由一郎
    • Journal Title

      Bacterial Adherence & Biofilms 22

      Pages: 13-18

  • [Journal Article] 難治性エンドとバイオフィルム(2)根尖孔内・外側のバイオフィルムの特徴とその対処法2007

    • Author(s)
      恵比須繁之, 野杁由一郎
    • Journal Title

      歯界展望 110

      Pages: 1029-1035

  • [Journal Article] 難治性エンドとバイオフィルム(1)バイオフィルムは根尖孔内・外に存在!2007

    • Author(s)
      恵比須繁之, 野杁由一郎
    • Journal Title

      歯界展望 110

      Pages: 854-860

  • [Journal Article] 各種のPorphyromonas gingivalis菌株が形成するバイオフィルムに対すAzithromycinの影響2007

    • Author(s)
      野杁由一郎, 野口展生, 朝日陽子, 山口幹代, 恵比須繁之
    • Journal Title

      Bacterial Adherence & Biofilms 20

      Pages: 104-109

  • [Presentation] 種々のPorphyromonas gingivalis菌株が形成するバイオフィルムに対する抗生物質の影響2009

    • Author(s)
      前薗葉月, 野杁由一郎, 朝日陽子, 薮根敏晃, 上田未央, 恵比須繁之
    • Organizer
      第130回日本歯科保存学会春季学術大会
    • Place of Presentation
      北海道
    • Year and Date
      2009-06-12
  • [Presentation] Homoserine lactone analogs inhibited Porphyromonas gingivalis biofilm growth2009

    • Author(s)
      Asahi Y, Noiri Y, Igarashi G, Asai H, Suga H, Ebisu S
    • Organizer
      87th International Association for Dental Research
    • Place of Presentation
      Miami, USA
    • Year and Date
      2009-04-03
  • [Presentation] Effects of various antibiotics on Porphyromonas gingivalis biofilms2008

    • Author(s)
      Maezono H, Noiri Y, Ueda M, Noguchi N, Yabune T, Ebisu S
    • Organizer
      86th International Association Control for Dental Research
    • Place of Presentation
      Toronto, Canada.
    • Year and Date
      2008-07-05
  • [Presentation] ~口腔バイオフィルムの制御戦略を考える~根尖性歯周炎の難治化とバイオフィルム-その臨床像と対策-2008

    • Author(s)
      野杁由一郎
    • Organizer
      第128回日本歯科保存学会春季学術大会(シンポジウム)
    • Place of Presentation
      新潟
    • Year and Date
      2008-06-06
  • [Presentation] クオラムセンシング関連物質がPorphyromonas gingivalisのバイオフィルム形成に及ぼす影響の検索2008

    • Author(s)
      朝日陽子, 野杁由一郎, 恵比須繁之, 五十嵐潤, 浅井洋明, 菅裕明
    • Organizer
      第128回日本歯科保存学会春季学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2008-06-05
  • [Presentation] Oral biofilm-The actual state and controls2008

    • Author(s)
      Noiri Y
    • Organizer
      The 15th World Congress on Dental Traumatology (Symposium)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2008-01-14
  • [Presentation] Sub-MIC濃度のアジスロマイシンがPorphyromonas gingivalisのバイオフィルムに及ぼす影響2007

    • Author(s)
      前薗葉月, 野杁由一郎, 上田未央, 野口展生, 薮根敏晃, 恵比須繁之
    • Organizer
      日本歯周病学会50周年記念大会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-27

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Published: 2011-06-18   Modified: 2016-04-21  

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