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2008 Fiscal Year Final Research Report

The activation and regulation of protease-activated receptor in human dental pulp cells

Research Project

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Project/Area Number 19592212
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionNihon University

Principal Investigator

HASHIZUME Hideki  Nihon University, 松戸歯学部, 講師 (10256894)

Project Period (FY) 2007 – 2008
Keywordsプロテアーゼレセプター / 細胞内カルシウム / アンタゴニスト / アゴニスト
Research Abstract

ヒト歯髄細胞(HDP)におけるプロテアーゼレセプター(PARs)の生理的・病態生理学的役割について研究し、以下の事項を明らかにした。1.HDP におけるPARs のCharacterization2.HDP におけるPARsの活性化調節機能3・4.PARs 活性化ペプチド・アンタゴニストがHDP のCa2+動態に及ぼす影響5.プラスミンがHDP のCa2+に及ぼす影響6.PAR-1 活性化と歯髄炎の関係

  • Research Products

    (5 results)

All 2008 2007

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Plasmin is involved in inflammation via protease-activated receptor-1 activation in human dental pulp2008

    • Author(s)
      N.Kamio, H.Hashizume, S.Nakao, K.Matsushima, H.Sugiya
    • Journal Title

      Biochem. Pharmacol 15;75(10)

      Pages: 1974-1980

    • Peer Reviewed
  • [Journal Article] Protein kinase C synergistically stimulates tumor necrosis factor-a-induced secretion of urokinase-type plasminogen activator in human dental pulp cells2008

    • Author(s)
      Hideki Hahsizume, Naoto Kamio, Sumi Nakao, Kiyoshi Matsushima and Hiroshi Sugiya
    • Journal Title

      Journal of Physiological science 58(1)

      Pages: 83-86

    • Peer Reviewed
  • [Journal Article] IL-1b stimulates urokinase-type plasminogen activator expression and secretion in human dental pulp cells2007

    • Author(s)
      Naoto Kamio, Hideki Hahsizume, Sumi Nakao, Kiyoshi Matsushima and Hiroshi Sugiya
    • Journal Title

      Journal of Physiological science 28(6)

      Pages: 315-322

    • Peer Reviewed
  • [Presentation] 培養ヒト歯根膜細胞におけるプロテアーゼ受容体PARs(protease-activated receptors)の発現について2008

    • Author(s)
      室町幸一郎、神尾直人、橋爪英城、山浦賀弘、中尾寿美、松島潔
    • Organizer
      2008年秋季歯科保存学会,(第129回)
    • Place of Presentation
      富山
    • Year and Date
      2008-11-06
  • [Presentation] ヒト歯髄培養細胞におけるProtease Activity Reseptor-1を介した細胞内カルシウム動態とPGE2産生2007

    • Author(s)
      神尾直人、橋爪英城、武内ひとみ、三浦孝司、村上芳弘、松島潔
    • Organizer
      春季日本歯科保存学会(第126回)
    • Place of Presentation
      埼玉
    • Year and Date
      2007-06-08

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Published: 2010-06-10   Modified: 2016-04-21  

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