Development of artificial vascularized bone graft module

2009 Fiscal Year Final Research Report

• Project/Area Number: 19592229
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 補綴理工系歯学
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KOYAMA Yoshihisa Tokyo Medical and Dental University, 生体材料工学研究所, 助教 (70361714)
• Co-Investigator(Kenkyū-buntansha): TAKAKUDA Kazuo 東京医科歯科大学, 生体材料工学研究所, 教授 (70108223)
• Project Period (FY): 2007 – 2009
• Keywords: 骨再建 / 人工骨 / 小口径人工血管 / 人工血管柄付き人工骨

Research Abstract

In the bone reconstruction, since middle of bone defects is deficient in blood supply, osteogenesis is disadvantageous. However, small diameter artificial arteries are not developed. Therefore, large bone defects are rebuilt by vascularized bone graft. In this research, artificial bone with small diameter artificial arteries which can rebuild large bone defects was developed.

Research Products

• [Journal Article] Biological fixation of fibrous materials to bone using chitin/chitosan as a bone formation accelerator (2009)
  • Author(s): Tomoyuki KAWAI, Takeki YAMADA, Akio YASUKAWA, Yoshihisa KOYAMA, Takeshi MUNETA, Kazuo TAKAKUDA
  • Journal Title: Journal of Biomedical Materials Research Part B : Applied Biomaterials 88-1 Pages: 264-70
  • Peer Reviewed
• [Journal Article] Improvement of Biocompatibility of Chitosan Fiber Modified by Ca-Phosphate Deposition through an Alternate Soaking Process (2009)
  • Author(s): Tomohiko YOSHIOKA, Hiroshi ONOMOTO, Haruhiko KASHIWAZAKI, Nobuo INOUE, Yoshihisa KOYAMA, Kazuo TAKAKUDA, Junzo TANAKA
  • Journal Title: Materials Transactions 50-6 Pages: 1269-1272
  • Peer Reviewed
• [Journal Article] Implantation of canine umbilical cord blood-derived mesenchymal stem cells mixed with beta-tricalcium phosphate enhances osteogenesis in bone defect model dogs (2008)
  • Author(s): Byung Jun JANG, Ye Eun BYEON, Ji Hey LIM, Hak Hyun RYU, Wan Hee KIM, Yoshihisa KOYAMA, Masanori KIKUCHI, Kyung Sun KANG, Oh Kyeong KWEON
  • Journal Title: Journal of Veterinary Science 9-4 Pages: 387-93
  • Peer Reviewed
• [Journal Article] Effects of pore size and implant volume of porous hydroxyapatite/collagen (HAp/Col) on bone formation in a rabbit bone defect model (2008)
  • Author(s): Akio TSUCHIYA, Shinichi SOTOME, Yoshinori ASOU, Masanori KIKUCHI, Yoshihisa KOYAMA, Tetsuro OGAWA, Junzo TANAKA, Kenichi SHINOMIYA
  • Journal Title: Journal of Medical and Dental Science 55-1 Pages: 91-99
  • Peer Reviewed
• [Journal Article] Reconstruction of Bone Fenestration on Mandiblar by the Guided Bone Regeneration Methods with β-TCP/PLGC Membranes (2007)
  • Author(s): Yoshihisa KOYAMA, Masanori KIKUCHI, Kazuya EDAMURA, Katsuyoshi NAGAOKA, Shigeo TANAKA, Junzo TANAKA, Kazuo TAKAKUDA
  • Journal Title: Journal of Nanoscience Nanotechnology 7-2 Pages: 859-861
  • Peer Reviewed
• [Journal Article] Material Design of Bioabsorbable Inorganic/Organic Composites for Bone Regeneration (2007)
  • Author(s): Kazuo TAKAKUDA, Yoshihisa KOYAMA, Hiroko MATSUMOTO, Noriaki SHIRAHAMA, Kazumi AKITA, Daisuke Shoji, Tetsuro OGAWA, Masaniri KIKUCHI, Junzo TANAKA
  • Journal Title: Journal of Nanoscience and Nanotechnology 7-2 Pages: 738-741
  • Peer Reviewed
• [Journal Article] In Vivo Evaluation of Hydroxyapatite Nano-Coating on Polyester Artificial Vascular Grafts and Possibility as Soft-Tissue Compatible Material
  • Author(s): Hiroyuki KADONO, Tsutomu FURUZONO T, Miwa MASUDA, Masahiro OKADA, Mitsuki UEKI, Keiichi TAKAMIZAWA, Ryoichi TANAKA, Kunio MIYATAKE, Yoshihisa KOYAMA, Kazuo TAKAKUDA
  • Journal Title: ASAIO Journal (in press)
  • Peer Reviewed
• [Journal Article] Bioabsorbable device for small-caliber vessel anastomosis
  • Author(s): Kazunori UEDA, Tomokazu MUKAI, Shizuko ICHINOSE, Yoshihisa KOYAMA, Kazuo TAKAKUDA
  • Journal Title: Microsurgery (in press)
  • Peer Reviewed
• [Presentation] Efficacy of bone regeneration with bioabsorbable organic/inorganic composite barrier membranes (2009)
  • Author(s): Yoshihisa KOYAMA, Masanori KIKUCHI, Kazuya EDAMURA, Shigeo TANAKA, Kazuo TAKAKUDA
  • Organizer: Third International Conference on Mechanics of Biomaterials and Tissues
  • Place of Presentation: Hilton Clearwater Beach Resort, Clearwater, FL, USA
  • Year and Date: 20091213-20091217
• [Presentation] イヌ脛骨離断骨欠損部再生におけるアパタイト/コラーゲン一軸連通多孔体気孔率の影響 (2009)
  • Author(s): 菊池正紀, 青木康至, 枝村一弥, 小山富久, 高久田和夫, 田中茂男
  • Organizer: 第21回アパタイト研究会
  • Place of Presentation: 福岡市
  • Year and Date: 20091200
• [Presentation] Regeneration of Dog's Segmental Bone Defect using Unidirectional Porous Hydroxyapatite/Collagen Composite (2009)
  • Author(s): Masanori KIKUCHI, Koji AOKI, Kazuya EDAMURA, Yoshihisa KOYAMA, Kazuo TAKAKUDA, Shigeo TANAKA
  • Organizer: The 26th International Japan-Korea Seminar on Ceramics
  • Place of Presentation: Tsukuba, Ibaraki, Japan
  • Year and Date: 20091100
• [Presentation] Effect of porosity of unidirectional porous hydroxyapatite/collagen bone-like nanocomposite on regeneration of critical tibial defect of dog (2009)
  • Author(s): Masanori KIKUCHI, Koji AOKI, Kazuya EDAMURA, Yoshihisa KOYAMA, Kazuo TAKAKUDA, Shigeo TANAKA
  • Organizer: 2009 MRS Fall Meeting
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 20091100
• [Presentation] Canine critical bone defect regeneration using unidirectional porous Hydroxyapatite/Collagen device (2009)
  • Author(s): Koji AOKI, Kazuya EDAMURA, Yoshihisa KOYAMA, Masanori KIKUCHI, Shigeo TANAKA
  • Organizer: 22nd International Symposium on Ceramics in Medicine (Bioceramics 22)
  • Place of Presentation: Hotel Inter-Brgo, Daegu, Korea
  • Year and Date: 20091026-20091029
• [Presentation] Bone Regeneration with beta-TCP/PLGC membranes (2009)
  • Author(s): Yoshihisa KOYAMA, Masanori KIKUCHI, Kazuya EDAMURA, Shigeo TANAKA, Oh-Kyeong KWEON, Kazuo TAKAKUDA
  • Organizer: 22nd International Symposium on Ceramics in Medicine (Bioceramics 22)
  • Place of Presentation: Hotel Inter-Brgo, Daegu, Korea
  • Year and Date: 20091026-20091029
• [Presentation] ハイドロキシアパタイト/コラーゲン複合体膜から作製した連通性多孔体による骨形成 (2009)
  • Author(s): 小山富久, 高久田和夫, 菊池正紀
  • Organizer: 第17回顎顔面バイオメカニクス学会学術講演会
  • Place of Presentation: 株式会社ヨシダ名古屋ショールーム研修センター, 名古屋市
  • Year and Date: 20091003-20091004
• [Presentation] ハイドロキシアパタイト/コラーゲン複合体膜から作製した連通性多孔体による骨再生 (2009)
  • Author(s): 小山富久, 菊池正紀, 高久田和夫
  • Organizer: 第54回日本歯科理工学会学術講演会
  • Place of Presentation: かごしま県民交流センター, 鹿児島市
  • Year and Date: 20091001-20091002
• [Presentation] 水酸アパタイト/コラーゲンナノ複合体膜から作製した連通性多孔体による脛骨離断欠損修復 (2009)
  • Author(s): 菊池正紀, 小山富久, 高久田和夫, 枝村一弥, 田中茂男
  • Organizer: 日本セラミックス協会2009年年会
  • Place of Presentation: 東京理科大学野田校舎, 野田市
  • Year and Date: 20090322-20090324
• [Presentation] 多孔質ハイドロキシアパタイト/コラーゲン長期移植時の経過観察/多孔質ハイドロキシアパタイト/コラーゲン長期移植時の経過観察 (2008)
  • Author(s): 望月直美, 柴崎幹生, 上坂優子, 高山知士, 塩谷慎吾, 平野昌弘, 菊池正紀, 小山富久, 高久田和夫, 四宮謙一, 早乙女進一
  • Organizer: 第28回整形外科セラミック・インプラント研究会
  • Place of Presentation: 崎陽軒本店会議室 (横浜市)
  • Year and Date: 20081206-20081207
• [Presentation] 生体吸収性骨補填材の骨再生の一考察 (2008)
  • Author(s): 小山富久, 高久田和夫, 枝村一弥, 田中茂男, 菊池正紀, 権五鏡, 吉田紳一郎, 望月直美
  • Organizer: 第16回顎顔面バイオメカニクス学会学術講演会
  • Place of Presentation: 佐賀大学医学部臨床大講堂 (佐賀市)
  • Year and Date: 20081115-20081116
• [Presentation] 水酸アパタイト/コラーゲン一軸連通気孔性人工骨の骨組織反応 (2008)
  • Author(s): 菊池正紀, 小山富久, 高久田和夫, 枝村一弥, 田中茂男
  • Organizer: 第16回顎顔面バイオメカニクス学会学術講演会
  • Place of Presentation: 佐賀大学医学部臨床大講堂 (佐賀市)
  • Year and Date: 20081115-20081116
• [Presentation] 生体吸収性カフによる小血管の吻合 (2008)
  • Author(s): 高久田和夫, 上田一徳, 桑崎雄揮, 小山富久
  • Organizer: 第16回顎顔面バイオメカニクス学会学術講演会
  • Place of Presentation: 佐賀大学医学部臨床大講堂 (佐賀市)
  • Year and Date: 20081115-20081116
• [Presentation] Critical Bone Defect Regeneration using Unidirectional Porous Scaffold Composed of Hydroxyapatite/Collagen Bone-Like Nanocomposite Membrane (2008)
  • Author(s): Masanori KIKUCHI, Kazuya EDAMURA, Yoshihisa KOYAMA, Kazuo TAKAKUDA, Shigeo TANAKA
  • Organizer: Asian Bioceramics Symposium 2008
  • Place of Presentation: Chennai, India
  • Year and Date: 20081100
• [Presentation] Enhanced osteogenesis of canine allogenic umbilical cord blood-delived mesenchymal stem cells associated with beta-Tricalcium Phosphate (2008)
  • Author(s): Ye-Eun BYEON, Hak-Hyun RYU, Yoshihisa KOYAMA, Masanori KIKUCHI, Sae-Rom LEE, Min-Soo SEO, Wan Hee KIM, Kyung-Sun KANG, Oh-Kyeong KWEON
  • Organizer: 2008 Annual Conference of Tissue Engineering and Regenerative Medicine International Society-Asian Pacific Region
  • Place of Presentation: Chien-Tan Overseas Youth Activity Center, Taipei, Taiwan
  • Year and Date: 20081100
• [Presentation] 生体吸収性骨再生材料の開発 (2008)
  • Author(s): 小山富久, 菊池正紀, 高久田和夫
  • Organizer: 第23回日本歯科産業学会学術講演会
  • Place of Presentation: 東京医科歯科大学歯学部特別講堂 (東京)
  • Year and Date: 20080719-20080720
• [Presentation] Biological Reactions of Hydroxyapatite/Collagen Self-Organized Nanocomposite Membrane and Its Roll-up Scaffold (2008)
  • Author(s): Masanori KIKUCHI, Yoshihisa KOYAMA, Kazuo TAKAKUDA, Shigeo TANAKA
  • Organizer: 8th World Biomaterials Congress
  • Place of Presentation: RAI Congress Centre, Europaplein, Amsterdam, Netherlands
  • Year and Date: 20080500
• [Presentation] 水酸アパタイト/コラーゲンナノ複合体膜からなる連通性多孔体の作成 (2008)
  • Author(s): 菊池正紀, 小山富久, 高久田和夫, 田中茂男
  • Organizer: 日本セラミックス協会2008年年会
  • Place of Presentation: 長岡技術科学大学 (長岡市)
  • Year and Date: 20080320-20080322
• [Presentation] Preparation of Interconnected Porous Scaffold using Hydroxyapatite/Collagen Bone-Like Nanocomposite Membrane and Its Biological Reactions (2008)
  • Author(s): Masanori KIKUCHI, Yoshihisa KOYAMA, Kazuo TAKAKUDA, Shigeo TANAKA
  • Organizer: Materials Research Society 2008 Spring Meeting
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 20080300
• [Presentation] 生体吸収性材料を用いた新規小血管吻合用カフ (2008)
  • Author(s): 上田一徳, 國分亮, 桑崎雄揮, 長谷川由佳, 服部奈々, 渡部竜創, 小山富久, 高久田和夫
  • Organizer: 第20回 日本機械学会バイオエンジニアリング講演会
  • Place of Presentation: 芝浦工業大学豊洲キャンパス (東京)
  • Year and Date: 20080125-20080126
• [Presentation] Preparation of Roll-Up Type Scaffold Composed of Hydroxyapatite/Collagen Bone-Like Nanocomposite (2007)
  • Author(s): Masanori KIKUCHI, Yoshihisa KOYAMA, Kazuo TAKAKUDA, Shigeo TANAKA
  • Organizer: 1st Asian Biomaterials Congress
  • Place of Presentation: Epocal Tsukuba, Tsukuba, Ibaraki, Japan
  • Year and Date: 20071200
• [Presentation] Hydroxyapatite/Collagen Self-Organized Nanocomposite Materials for Bone Regeneration Composite at Lake Louise (2007)
  • Author(s): Masanori KIKUCHI, Teruaki YOSHIDA, Yoshihisa KOYAMA, Kazuo TAKAKUDA
  • Place of Presentation: Lake Louise, Canada
  • Year and Date: 20071100
• [Presentation] Efficacy of Bone Regeneration with Bioabsorbable Composite GBR Membranes (2007)
  • Author(s): Yoshihisa KOYAMA, Masanori KIKUCHI, Hiroo MIYAIRI, Kazuo TAKAKUDA
  • Organizer: International Dental Materials Congress 2007
  • Place of Presentation: The Imperial Queen Park Hotel, Bangkok, Thailand
  • Year and Date: 20071028-20071029
• [Presentation] キチンの応用による繊維構造の骨固定促進 (2007)
  • Author(s): 高久田和夫, 川合智行, 安川明夫, 小山富久
  • Organizer: 第15回顎顔面バイオメカニクス学会学術講演会
  • Place of Presentation: 北海道医療大学札幌サテライトキャンパス (札幌市)
  • Year and Date: 20070824-20070825
• [Presentation] 人工血管素材としてのナノ無機複合体と in vivo 評価 (2007)
  • Author(s): 古薗勉, 益田美和, 植木光樹, 角野弘幸, 小粥康充, 田中良一, 小山富久, 高久田和夫, 岡田正弘
  • Organizer: 第56回高分子学会年次大会
  • Place of Presentation: 国立京都国際会館 (京都市)
  • Year and Date: 20070529-20070531
• [Presentation] 生体吸収性接着剤による血管の接着 (2007)
  • Author(s): 小山富久, 永井正洋, 宮入裕夫, 高久田和夫
  • Organizer: 第49回日本歯科理工学会学術講演会
  • Place of Presentation: 札幌コンベンションセンター (札幌市)
  • Year and Date: 20070512-20070513