2009 Fiscal Year Final Research Report
A study of the influence of occlusal activity on the characteristics of tongue and masticatory muscles using non-occlusal model animal
| Project/Area Number |
19592266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Tsurumi University |
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Principal Investigator |
ISHIKAWA Chieko Tsurumi University, 歯学部, 助教 (70176163)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANE Akira 鶴見大学, 歯学部, 教授 (20166763)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 小眼球症マウス / 咬合 / シナプス形成 / AChR転換 / AChR除去 / mitf |
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| Research Abstract |
The present study attempted to elucidate the contribution of occlusal activity to synaptogenesis in masticatory muscles. In the masseter of the mi/mi, the nAChR elimination initiated, but did not progress normally after 3 weeks of age, when the occlusal activity emerged in the +/+ mouse, whereas the nAChR switch progressed normally during the entire period of synaptogenesis. The mRNA expression patterns of nAChR subunits in the temporalis and digastric of the mi/mi differed from those in its masseter. These findings suggest that, in the masseter, occlusal activity is essential for the completion of nAChR elimination, but not for the nAChR switch, and that the contribution of occlusal activity to synaptogenesis varies among the masticatory muscles.
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[Journal Article] Effects of clenbuterol, aβ2-adrenergic agonist, on sizes of masseter, temporalis, digastric, and tongue muscles2009
Author(s)
ISHIKAWA, C., OGAWA, T., IKAWA, T., YAMANE, A
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Journal Title
Open Dent. J 3
Pages: 191-196
Peer Reviewed
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[Journal Article] Extracellular matrix-mediated tissue remodeling following axial movement of teeth2007
Author(s)
LUAN, X., ITO, Y., HOLLIDAY, S., WALKER, C., DANIELL, J., GALANG, T.M., FUKUI, T. YAMANE, A., BEGOLE, E., EVANS, C., DIEKWISCH, T.G. H
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Journal Title
J. Histochem. Cytochem 55(2)
Pages: 127-140
Peer Reviewed
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[Journal Article] BMP2, BMP4, and their receptors are expressed in the differentiating muscle tissues of mouse embryonic tongue2007
Author(s)
SUGA, T., FUKUI, T., SHINOHARA, A., LUAN, X., DIEKWISCH, T.G.H., MORITO, M., YAMANE, A
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Journal Title
Cell Tissue Res 329(1)
Pages: 103-117
Peer Reviewed
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[Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice
Author(s)
NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A., ASADA, Y
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Journal Title
Pediatric Dent. J (In press)
Peer Reviewed
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[Journal Article] BMP-2 Regulates the Formation of Oral Sulcus in Mouse Tongue by Altering the Balance between TIMP-1 and MMP-13
Author(s)
FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y., YAMANE, A
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Journal Title
Peer Reviewed
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[Presentation] Function of occlusal activity in the synaptogenesis and myogenesis of masseter muscle2008
Author(s)
YAMANE, A., KOUTA, Y., SUGA, T., KANEKO, N., MORITO, N., ASADA, Y
Organizer
Gordon Research Conference "Craniofacial morphogenesis and tissue regeneration"
Place of Presentation
Il Ciocco, Italy
Year and Date
2008-02-12
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[Presentation] Effects of occlusal activity on masseter myogenesis and synaptogenesis2007
Author(s)
KOUTA, Y., YAMANE, A., TASHIMA, I., TOMOHIRO, T., ARITA, K., ASADA, Y
Organizer
55th Annual meeting of JADR
Place of Presentation
鶴見大学
Year and Date
2007-11-08
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