2009 Fiscal Year Final Research Report
The induction mechanism of new bone formation by sintered carbonate apatite grafted into bone
| Project/Area Number |
19592268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
補綴理工系歯学
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| Research Institution | Asahi University |
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Principal Investigator |
KOGAYA Yasutoku Asahi University, 歯学部, 准教授 (30076046)
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| Co-Investigator(Kenkyū-buntansha) |
DOI Yutaka 朝日大学, 歯学部, 教授 (40116067)
KUBO Kin-ya 星城大学, リハビリテーション学部, 教授 (00329492)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 骨 / 炭酸アパタイト / 新生骨誘起 / 硫酸化複合糖質 |
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| Research Abstract |
The sintered carbonate apatite grafted into rat bone at one month after implantation was coated with fibroblast-like cells, osteoblast-like cells, and/or multi-nucleated giant cells. Although part of the sintered carbonate apatite was absorbed by multinucleated giant cells or macrophages, adjacent to the surface of the survived carbonate apatite, moderate electron dense layer of about 100nm in width, was observed, where newly formed bone was frequently formed. Small type of HID-TCH-SP stain deposits that represent sulfated glycoconjugates or sulfated glycoproteins were detected over the layer.
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