2009 Fiscal Year Final Research Report
Development of novel treatment for oral cancer due to analysis of DNA repair system
| Project/Area Number |
19592300
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
OSAKI Tokio Kochi University, 名誉教授 (70031995)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya 高知大学, 教育研究部医療学系, 教授 (00200824)
UETA Eisaku 高知大学, 教育研究部医療学系, 講師 (10203431)
KAMATANI Takaaki 高知大学, 医学部附属病院, 助教 (00315003)
SASABE Eri 高知大学, 教育研究部医療学系, 助教 (40363288)
SATAKE Hidetaka 高知大学, 教育研究部医療学系, 助教 (10304685)
TATEISHI Yoshihisa 高知大学, 医学部附属病院, 助教 (20372732)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | 口腔扁平上皮癌 / DNA損傷 / 放射線 / Rad51 / 17-AAG / アポトーシス |
|---|
| Research Abstract |
An inhibitor of heat shock protein 90, 17-AAG, inhibits homologous recombination mechanism to repair DNA damage in oral squamous cell carcinoma cells via the inhibition of Rad51 expression. The combination of 17-AAG with ionizing irradiation seems to be a useful strategy for oral cancer treatment.
|
-
-
-
-
-
[Journal Article] EGCG-targeted p57/KTP2 reduces tumorigenicity of oral carcinoma. cells: Role of c-Jun N-terminal kinase.2007
Author(s)
Yamamoto T, Digumarthi H, Aranbayeva. Z, Wataha J, Lewis j, Messer R, Qin H, Dickinson D, Osaki T, Schuster GS, Hsu S
-
Journal Title
Toxicol Appl Pharmacol 224(3)
Pages: 318-325
-
-
-
-
-
-
-
