2008 Fiscal Year Final Research Report
Antiangiogenic gene therapy with low-dose chemotherapy enhances antitumor activity against oral cancer
| Project/Area Number |
19592322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
OMI Yasushi Kanagawa Dental College, 歯学部, 助教 (10318892)
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| Co-Investigator(Kenkyū-buntansha) |
LEE Ushaku 神奈川歯科大学, 歯学部, 助教 (90288085)
MATSUMOTO Goichi 神奈川歯科大学, 歯学部, 准教授 (60199867)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 口腔癌 / 遺伝子治療 / アンジオスタチン / エンドスタチン / NK4 / CDDP |
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| Research Abstract |
抗血管新生遺伝子治療単独群[アンジオスタチンplasmid DNA (100μg)、エンドスタチンplasmid DNA(100 μg)、NK4 plasmid DNA (100 μg)]に比較し、CDDP(1.5mg/kg ; 1週間に5回で3週間継続)併用投与群において有意な腫瘍抑制効果を認めた。
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