2009 Fiscal Year Final Research Report
Effects of sexual hormones for osteoclasts of temporomandibular joint disorders
| Project/Area Number |
19592323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
KANEYAMA Keiseki Kanazawa Medical University, 医学部, 講師 (50329380)
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| Co-Investigator(Kenkyū-buntansha) |
SEGAMI Natsuki 金沢医科大学, 医学部, 教授 (40148721)
NAGAO Toshikazu 金沢医科大学, 医学部, 助教 (70387364)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 顎関節症 / 破骨細胞 / 破骨細胞分化促進因子 / 破骨細胞分化抑制因子 / 滑液 / 滑膜 / ビスフェノールA / 性ホルモン |
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| Research Abstract |
To investigate the possible influences of estrogen on the development of osteoarthritis (OA), the effects of Bisphenol-A (BPA), an analogue of estrogen, on the development of the temporomandibular joints in mice fetuses were examined. The temporomandibular joints was reduced in volume and cell number in the BPA groups. The low concentration groups (0.2-2μg/kg) demonstrated the smallest volume and lowest cell number.BPA administration appeared to affect the development of the mandibular condyle in mice.
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