2010 Fiscal Year Final Research Report
Experimental study on development and application in beagles with cleft lip/palate
| Project/Area Number |
19592326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
FURUKAWA Hiroo Aichi Gakuin University, 心身科学部, 准教授 (70291763)
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| Co-Investigator(Kenkyū-buntansha) |
KOYASU Kazuhiro 愛知学院大学, 歯学部, 講師 (50183348)
NAITO Munetaka 愛知学院大学, 歯学部, 准教授 (20167539)
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| Project Period (FY) |
2007 – 2010
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| Keywords | イヌ / ヒト / 先天異常 / 口唇裂 / 口蓋裂 / 心臓異常 / 大血管異常 |
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| Research Abstract |
The Jpanese breeder network of the beagle was able to be established in the first year. We obtained jaw deformity beagles (for breeding , by two male females) using the network. Aiming at the establishment of the cleft lip and palate natural occurrence beagle system, we tried them as a mating individual. From a reason peculiar to an individual, however, do not readily become pregnant, we were not able to acquire a second cleft lip/palate beagle or jaw deformity beagle.
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[Journal Article] Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip.2009
Author(s)
Suzuki S, Marazita ML, Cooper ME, Miwa N, Hing A, Jugessur A, Natsume N, Shimozato K, Ohbayashi N, Suzuki Y, Niimi T, Minami K, Yamamoto M, Altannamar TJ, Erkhembaatar T, Furukawa H, Daack-Hirsch S, L'heureux J, Brandon CA, Weinberg SM, Neiswanger K, Deleyiannis FW, de Salamanca JE, Vieira AR, Lidral AC, Martin JF, Murray JC.
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Journal Title
Am J Hum Genet. 84(3)(Epub 2009 Feb 26)
Pages: 406-11
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