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2008 Fiscal Year Final Research Report

Periodontal Tissue Regeneration using the Bone Marrow Mesenchymal Stem Cells with the Calcified-Tissue-Conductive Collagen Composite

Research Project

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Project/Area Number 19592392
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

FUJII Takeo  Health Sciences University of Hokkaido, 大学院歯学研究科・個体差医療科学センター, 准教授 (30173389)

Co-Investigator(Kenkyū-buntansha) SAITO Takashi  北海道医療大学, 大学院歯学研究科う蝕制御治療学分野, 教授 (40265070)
ABIKO Yoshihiro  北海道医療大学, 大学院歯学研究科個体差医療科学センター, 教授 (90260819)
SAITO Masato  北海道医療大学, 大学院歯学研究科個体差医療科学センター, 講師 (50337036)
Project Period (FY) 2007 – 2008
Keywords歯周外科学 / 再生治療
Research Abstract

重度歯周炎によって垂直的・水平的骨欠損を伴う破壊された歯周組織の広範囲な再生を目指す歯周組織再生治療法を確立するために、骨髄間葉系幹細胞培養系を利用する新しい石灰化誘導性複合体型生体素材の開発研究を行った。本研究において、組織再生量の決め手となるコラーゲンゲル3次元培養内で、細胞増殖を助長する線維芽細胞成長因子(FGF)を応用することで、石灰化硬組織形成の基盤となる生体材料の開発に一定の目途がついた。

  • Research Products

    (6 results)

All 2008 2007 Other

All Journal Article (4 results) Presentation (2 results)

  • [Journal Article] The effects of antibiotics on in vitro biofilm model of periodontal disease2008

    • Author(s)
      A.Tamura, T.Ara, Y.Imamura, T.Fujii P-L.Wang
    • Journal Title

      Eur J Med Res 13

      Pages: 439-445

  • [Journal Article] Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2: Randomized Controlled PhaseII Clinical Trial2008

    • Author(s)
      M.Kitamura, K.Nakashima, Y.Kowashi, T.Fujii, H.Shimauchi, et al
    • Journal Title

      ProsOne 3

      Pages: 1-11

  • [Journal Article] Antibiotic strategies for the treatment of periodontal disease2008

    • Author(s)
      FUJII Takeo, TSUJI Hifumi
    • Journal Title

      Clinical Research in Dentistry 5

      Pages: 54-65

  • [Journal Article]

    • Pages
      0
  • [Presentation] Effects of Melatonin on Pro-inflammatory Cytokine Production in PGE2-activated Human Gingival Fibroblasts in vitro2008

    • Author(s)
      T.Fujii, P-L Wang, Y.Terada, H.Tsuji, PC Baehini
    • Organizer
      5th European Calcified Tissue Society
    • Year and Date
      20080000
  • [Presentation] Application of Phosphophoryn/collagen composite to horizontal bone loss in periodontal defects in vivo2007

    • Author(s)
      T.Fujii, T.Lombardi, P.C.Baehni, et.a
    • Organizer
      34th European Calcified Tissue Society
    • Year and Date
      20070000

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Published: 2010-06-10   Modified: 2016-04-21  

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