2009 Fiscal Year Final Research Report
Search for target molecule for immunotherapy based on Porphyromonas gingivalis genome analysis
| Project/Area Number |
19592394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
SHIBATA Yasuko Nihon University, 松戸歯学部, 講師 (90133438)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 感染症 / ゲノム / 細菌 / 歯学 / 免疫学 |
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| Research Abstract |
Porphyromonas gingivalis (P.gingivalis), an important periodontal pathogen in periodontitis, possesses a variety of virulent factors, and are classified into six genotypes (types I-V and Ib) based on the genotype of fimbriae A (fimA). The epidemiological studies shown that fimA II strains is harbored in most of the aggressive periodontal patients, and are thought to be strongest related to aggressive periodontitis, furthermore, fimA II is most frequently detected in patients with cardiovascular disease. In this report, to develop passive immunotherapy, we tryied to search the new pathogen of this type II P.gingivalis using the genomic and proteomic techniques, and then mouse monoclonal antibody (MAb), which neutralizes virulent factor activity, is constructed.
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[Journal Article] IL-1・stimulates IL-8 production, including prostaglandin E2 receptor EP4-triggered pathways, in synoviocyte MH7A cells.2009
Author(s)
Shibata Y, Kasai H, Shimada M, Koitabashi T, Arai T, Sai R, Terao H, Horikiri M, Negishi H, Miyazawa K, Abiko Y
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Journal Title
Mol Med Reports 2(3)
Pages: 359-363
Peer Reviewed
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[Journal Article] Proteomic analysis of apoptosis induced by xanthoangelol, a major constituent of Angelica keiskei, in neuroblastoma.2008
Author(s)
Motani K, Tabata K, Kimura Y, Okano S, Shibata Y, Abiko Y, Nagai H, Akihisa T, Suzuki T
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Journal Title
Biol Pharm Bull 31(4)
Pages: 618-626
Peer Reviewed
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