2009 Fiscal Year Final Research Report
Analysis of pathogenic mechanism of chronic pain in oro-facial aria using a index of CRF gene expression in hypothalamus
| Project/Area Number |
19592401
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SHOJI Noriaki Tohoku University, 病院, 講師 (70250800)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Koreaki 東北福祉大学, 総合福祉学部, 講師 (30361158)
SASANO Takashi 東北大学, 大学院・歯学研究者, 教授 (10125560)
SATOH Shizuko 東北大学, 大学院・歯学研究者, 助教 (60225274)
SUGAWARA Yumiko 東北大学, 病院, 助教 (30235866)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 痛みストレス / 視床下部-下垂体-副腎系 / CRF遺伝子 / hnRNA |
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| Research Abstract |
Pain is one of the physical stressor for humans. In this study, we performed quantitative analysis of CRF gene transcription in hypothalamic PVN under the condition of tongue pain stress in rats. Plasma adrenocorticotropic hormone (ACTH) secretion was peak at 30 min after the capsaicin injection to tongue prior to gradually increasing of plasma corticosterone, indicating that tongue pain is stressor enough to up-regulate hypothalamo-pituitary- adrenocortical axis. CRF hnRNA 15 min after the injection was up-regulated 3 fold than that of control rats. This report is the first study which succeeded to detect CRF hnRNA by quantitative real-time PCR analysis.
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Research Products
(12 results)
