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2009 Fiscal Year Final Research Report

Elucidation of the relevance between oral health and common systemic diseases -an approach for early detection and treatment of periodontitis-

Research Project

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Project/Area Number 19592420
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionOsaka Dental University

Principal Investigator

NAGANO Yutaka  Osaka Dental University, 歯学部, 講師 (80228048)

Co-Investigator(Kenkyū-buntansha) DOMAE Naochika  大阪歯科大学, 歯学部, 教授 (60115889)
KAMBARA Masaki  大阪歯科大学, 歯学部, 教授 (90103085)
MIYAKE Taturou  大阪歯科大学, 歯学部, 准教授 (40200141)
Project Period (FY) 2007 – 2009
Keywords社会歯学 / 内科 / 歯学 / メタボリックシンドローム / 歯周炎
Research Abstract

In this project, we investigated the relevance of periodontal condition and markers for common systemic diseases. The results revealed that, in middle-aged subjects, the abnormalities of systemic data were seen more frequently in subjects with periodontal problems. We also looked at the mechanisms of bone resorption under chronic inflammatory condition, and demonstrated that osetoprotegerin, a molecule that regulate bone resorption, was clearly induced when monocytes differentiate into macrophages. The results are considered to be useful for early detection of periodontitis and prevention of alveolar bone loss.

  • Research Products

    (10 results)

All 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Book (3 results)

  • [Journal Article] Induction of osteoprotegerin mRNA during differentiation of monocytes into macrophages.2009

    • Author(s)
      NOTOHARA Y, NAGANO Y, DOMAE N, UEDA M.
    • Journal Title

      J Osaka Dent Univ 43

      Pages: 37-42

    • Peer Reviewed
  • [Journal Article] Emdogain stimulates matrix degradation by osteoblasts.2008

    • Author(s)
      GODA S, INOUE H, KANESHITA Y, NAGANO Y, IKEO T, IIDA J, DOMAE N.
    • Journal Title

      J Dent Res 87(8)

      Pages: 782-787

    • Peer Reviewed
  • [Presentation] 白血球細胞でのosteoprotegerin発現の誘導と歯周病病変における意義2009

    • Author(s)
      能登原靖宏, 他
    • Organizer
      日本歯周病学会2009春季学術大会(第52回)
    • Place of Presentation
      岡山コンベンションセンター(岡山県)
    • Year and Date
      2009-05-15
  • [Presentation] 単球系細胞のマクロファージ化に伴うosteoprotegerin mRNAの誘導2008

    • Author(s)
      能登原靖宏, 他
    • Organizer
      第516回大阪歯科学会
    • Place of Presentation
      大阪歯科大学(大阪府)
    • Year and Date
      2008-12-13
  • [Presentation] Osteoprotegerin is induced during differentiation of monocytes.2008

    • Author(s)
      NOTOHARA Y, 他
    • Organizer
      The American Academy of Periodontology 94th Annual Meeting
    • Place of Presentation
      Seattle, USA.
    • Year and Date
      2008-09-07
  • [Presentation] 動脈硬化の危険因子と歯周状態との関連2008

    • Author(s)
      長野豊, 他
    • Organizer
      第40回日本動脈硬化学会総会
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Year and Date
      2008-07-10
  • [Presentation] THP-1細胞のマクロファージ化に伴うosteoprotegerin mRNAの誘導.2008

    • Author(s)
      能登原靖宏, 他
    • Organizer
      日本歯周病学会2008春季学術大会(第52回)
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2008-04-25
  • [Book] 動脈硬化. 臨床分子細胞生物学2009

    • Author(s)
      長野豊
    • Total Pages
      267-276
    • Publisher
      メディカルレビュー社
  • [Book] プロブコール. 酸化ストレスと心血管病2007

    • Author(s)
      長野豊
    • Total Pages
      237-242
    • Publisher
      東京:日本医学出版
  • [Book] 高脂血症・動脈硬化. 新臨床栄養学2007

    • Author(s)
      長野豊
    • Total Pages
      334-341
    • Publisher
      東京:医学書院

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Published: 2011-06-18   Modified: 2016-04-21  

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