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2008 Fiscal Year Final Research Report

Analysis of the molecular mechanisms of immunological memory responses against polysaccharides vaccines

Research Project

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Project/Area Number 19599006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TSUIJI Makoto  Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 (90302611)

Project Period (FY) 2007 – 2008
Keywords免疫学 / 免疫記憶 / 糖鎖 / 感染症 / 肺炎球菌 / ワクチン
Research Abstract

莢膜糖鎖を有する感染性細菌は免疫応答から逃れることにより病原性を発揮する特徴を有する。高齢者の死因トップである肺炎の最大原因菌である肺炎球菌は特徴的な莢膜糖鎖を有しており、宿主の加齢ともに弱った免疫応答から逃れ肺炎を引き起こす。そこで本研究はワクチンの改良法として臨床に還元できる知見を得ることを目的として、糖鎖ワクチン投与による免疫応答のマウスにおける詳細な解析を行った。

  • Research Products

    (7 results)

All 2008 2007

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results)

  • [Journal Article] Efficient generation of monoclonal antibodies from single human B cells bysingle cell RT-PCR and expression vector cloning2008

    • Author(s)
      Tiller T, Meffre E, Yurasov S, Tsuiji M, Nussenzweig MC, Wardemann H
    • Journal Title

      J Immunol Methods 329

      Pages: 112-124

    • Peer Reviewed
  • [Journal Article] Autoreactive IgG(+) memory antibodies in patients with systemic erythematosus arise from nonreactive and polyreactive precursors2008

    • Author(s)
      Mietzner B, Tsuiji M, Scheid J, Velinzon K, Tiller T, Abraham K, Gonzalez JB, Pascual V, Stichweh D, Wardemann H,and Nussenzweig MC
    • Journal Title

      Proc Natl AcadSci USA 105

      Pages: 9727-9732

    • Peer Reviewed
  • [Journal Article] The amino acidsinvolved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2(CD301a and b)of mice2008

    • Author(s)
      Oo-Puthinan S, Maenuma K, Sakakura M, Denda-Nagai K, Tsuiji M, Shimada I, Nakamura-Tsuruta S, Hirabayashi J, BovinNV,and Irimura T
    • Journal Title

      Biochim Biophys Acta 1780

      Pages: 89-100

    • Peer Reviewed
  • [Journal Article] Identification and expression of human epiglycanin/MUC21 : a novel transmembrane mucin2008

    • Author(s)
      Itoh Y, Kamata-Sakurai M, Denda-Nagai K, Nagai S, Tsuiji M, Ishii-Schrade K, Okada K, Goto A, Fukuyama M,and Irimura T
    • Journal Title

      Glycobiology 18

      Pages: 74-83

    • Peer Reviewed
  • [Journal Article] Autoreactivity in human IgG(+)memory B cells2007

    • Author(s)
      TillerT, Tsuiji M, Yurasov S, Velinzon K, Nussenzweig MC,and Wardemann H
    • Journal Title

      Immunity 26

      Pages: 205-213

    • Peer Reviewed
  • [Presentation] Autoreactivity in human IgG+ memory B cells2007

    • Author(s)
      Tiller T, Tsuiji M, Yurasov S, Velinzon K, Nussenzweig MC and Wardemann H
    • Organizer
      Keystone symposia, Biology of Bcells in Health and Disease
    • Place of Presentation
      (ポスター発表)
    • Year and Date
      2007-02-10
  • [Presentation] IgG plasmablast and memory B cell antibodiesin patients with SLE.Keystone symposia2007

    • Author(s)
      Tsuiji M, Mietzner B, Scheid J, Feraoun N, Yurasov S, Velinzon K, Wardemann H and Nussenzweig MC
    • Organizer
      Biology of B cells in Health and Disease
    • Place of Presentation
      (ポスター発表)
    • Year and Date
      2007-02-09

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Published: 2010-06-10   Modified: 2016-04-21  

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