2009 Fiscal Year Final Research Report
Development of novel photo-cleavable linker for the target identification of bio-active compound using affinity resins
| Project/Area Number |
19599025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Hyogo University of Health Sciences |
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Principal Investigator |
AKITO Tanaka Hyogo University of Health Sciences, 薬学部, 教授 (30454789)
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| Project Period (FY) |
2007 – 2009
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| Keywords | アフィニティ樹脂 / ターゲット探索 / 生理活性物質 / 光反応 |
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| Research Abstract |
I have developed a photo-cleavable linker for identifications of the target proteins of attractive bio-active compounds. We here demonstrated that known target proteins such as FKBP12, CAII, and so on, were selectively eluted from affinity resins using our method, only by irradiation under protein-friendly mild conditions. This development is important for the identification.
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Research Products
(4 results)
