2009 Fiscal Year Final Research Report
Development of new analgesics and therapy for intractable pain
| Project/Area Number |
19603011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
SAKURADA Shinobu Tohoku Pharmaceutical University, 薬学部, 教授 (30075816)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Hirokazu 東北薬科大学, 薬学部, 准教授 (30360069)
WATANABE Chizuko 東北薬科大学, 薬学部, 助教 (90296020)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 難治性疼痛 / 鎮痛薬 / オピオイド / 内因性ペプチド / ジーンセラピー |
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| Research Abstract |
We investigated the mechanism for the reduced effectiveness of morphine in neuropathic pain stage in this project. With the mechanism investigated, we tried to develop the gene therapy for neuropathic pain. In addition, we also developed the new analgesic amidino-TAPA, which is extremely effective against neuropathic pain.
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