2011 Fiscal Year Final Research Report
Regulation of genome stability undernutritionalstarvation
| Project/Area Number |
19657039
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKASE Yukiko 京都大学, 放射線生物研究センター, 研究員 (80402923)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Tomohiro 京都大学, 放射線生物研究センター, センター長 (80212223)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 細胞情報伝達機構 |
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| Research Abstract |
The TSC-Rheb signaling pathway plays critical roles in the regulation of cell growthunder various conditions. In Schizosaccharomyces pombe, the amount of amino acid transporters at the cell surface is tightly regulated in response to environmental condition. However, how cellular localization of amino acid transporters is regulated under certain conditions remains obscure. Here we demonstrate that ubiquitin ligasePub1 and arrestin-like protein Any1 coordinate regulation of aminoacid transporters and TSC-Rheb signaling pathway controls this regulation.
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