2011 Fiscal Year Final Research Report
Molecular mechanisms for recognition and signal transduction of sex-specific peptides in the mouse vomeronasal organ
| Project/Area Number |
19677002
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TOUHARA Kazushige 東京大学, 大学院・農学生命科学研究科, 教授 (00280925)
|
|---|
| Project Period (FY) |
2007 – 2011
|
| Keywords | マウス / フェロモン / 鋤鼻器官 / 受容体 / ペプチド |
|---|
| Research Abstract |
We discovered a mouse male-specific peptide, named exocrine gland-secreting peptide 1(ESP1), that was released into tear fluids from the extraorbital lacrimal gland. ESP1 turned out to be a sex pheromone that enhanced female sexual receptive behavior upon male mounting, leading to the successful copulation in mice. Moreover, we revealed the molecular mechanisms and the neural pathway involved in decoding the ESP1 signal in the vomeronasal system. The ESP1-signal processing in the vomeronasal system appears to be mediated by the selective neural pathway via the specific vomeronasal receptor. This study provided the first functional link between a sex peptide pheromone and a behavioral output via a selective neural pathway activated by a specific receptor in the vomeronasal system.
|
-
[Journal Article] The male mouse pheromone ESP1 enhances female sexual receptive behavior through a specific vomeronasal receptor2010
Author(s)
Haga, S., Hattori, T., Sato, T., Sato, K., Matsuda, S., Kobayakawa, R., Sakano, H., Yoshihara, Y., Kikusui, T. and Touhara, K
-
Journal Title
Nature
Volume: 466
Pages: 118-122
Peer Reviewed
-
-
-
[Journal Article] The mouse ESP family : sex and strain differences, and implications in the vomeronasal sensory system2007
Author(s)
Kimoto, H., Sato, K., Nodari, F., Haga, S., Holy, T., and Touhara, K
-
Journal Title
Current Biology
Volume: 17
Pages: 1879-1884
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
