Molecular mechanisms of plant immunity and its suppression by pathogens

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19678001
• Research Category: Grant-in-Aid for Young Scientists (S)
• Allocation Type: Single-year Grants
• Research Field: Plant pathology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SHIRASU Ken The Institute of Physical and Chemical Research, 植物免疫研究チーム, チームリーダー (20425630)
• Project Period (FY): 2007 – 2011
• Keywords: 遺伝子 / ゲノム / シグナル伝達 / 植物 / 生理学

Research Abstract

本研究ではタンパク質の大規模解析ツールおよびゲノム解析ツールを整備して、植物免疫シグナル伝達系の重要タンパク質、及びその複合体の同定そしてその構造決定をし、その制御機構の分子メカニズムを明らかにすることを主目的とする。候補タンパク質として、植物免疫シャペロン複合体,や病原体由来のエフェクタータンパク質の構造を決定し、その免疫抑制機能を明らかにする。

Research Products

• [Journal Article] Horizontal gene transfer by the parasitic plant Striga hermonthica (2010)
  • Author(s): Yoshida, S., Maruyama, S., Nozaki, H., Shirasu, K.
  • Journal Title: Science (in press)
  • Peer Reviewed
• [Journal Article] Autophagy Negatively Regulates Cell Death by Controlling NPR1-Dependent Salicylic Acid Signaling during Senescence and the Innate Immune Response in Arabidopsis (2009)
  • Author(s): Yoshimoto K., Jikumaru Y., Kamiya Y., Kusano M., Consonni C., Panstruga R., Ohsumi Y., Shirasu K.
  • Journal Title: Plant Cell 60 Pages: 218-226
  • Peer Reviewed
• [Journal Article] The HSP90-SGT1 Chaperone Complex for NLR Immune Sensors (2009)
  • Author(s): Shirasu, K.
  • Journal Title: Annual Review of Plant Biology 60 Pages: 139-164
  • Peer Reviewed
• [Journal Article] Structural and functional analysis of SGT1-HSP90 core complex required for innate immunity in plants (2008)
  • Author(s): Kadota, Y., Amigues, B., Ducassou, L., Madaoui, H., Ochsenbein, F., Guerois, R., Shirasu, K.
  • Journal Title: EMBO reports 9 Pages: 1209-1215
  • Peer Reviewed
• [Journal Article] Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes (2008)
  • Author(s): Zhang, M., Boter, M., Li, K., Kadota, Y., Panaretou, B., Prodromou, C., Shirasu, K., Pearl, L.
  • Journal Title: EMBO J. 27 Pages: 2789-2798
  • Peer Reviewed
• [Journal Article] Negative regulation of PAMP-triggered immunity by E3 ubiquitin ligase triplet in Arabidopsis (2008)
  • Author(s): Trujillo, M., Ichimura, K., Casais, C., Shirasu, K.
  • Journal Title: Current Biology 18 Pages: 1396-1401
  • Peer Reviewed
• [Presentation] Structure and Function of the N-terminal Domain of Hsp90 in Complex with the CS-domain of Sgt1 (2008)
  • Author(s): Zhang. M, Boter. M, Li. K, Kadota. Y, Panaretou. B, Prodromou. C, Shirasu. K, Pearl. L
  • Organizer: 4th International Conference on The Hsp90 Chaperone Machine
  • Place of Presentation: Bavaria Germany
  • Year and Date: 20081000
• [Presentation] Structural and functional analysis of the SGT1-HSP90 chaperone complex required for NLR-protein dependent innate immunity (2008)
  • Author(s): Kadota. Y, Amigues. B, Guerois. R, Shirasu. K
  • Organizer: 4th International Conference on The Hsp90 Chaperone Machine
  • Place of Presentation: Bavaria Germany
  • Year and Date: 20081000
• [Presentation] Plant autophagy negatively regulates senescence by eliminating salicylic acid signaling (2008)
  • Author(s): Yoshimoto. K, Ohsumi. Y, Shirasu. K
  • Organizer: Gordon Research Conferences on Plant Senescence
  • Place of Presentation: South Hadley USA
  • Year and Date: 20080600
• [Book] Plant Mitogen-Activated Protein Kinase Cascades in Signaling Crosstalk, In "Signal Crosstalk in Plant Stress Responses"(Keiko Yoshioka and Kazuo Shinozaki eds) (2009)
  • Author(s): Takahashi, F., Ichimura, K., Shinozaki, K., Shirasu, K.
  • Total Pages: 23-38
  • Publisher: Wiley-Blackwell
• [Remarks] ホームページ
  • URL: http://ksg.psc.riken.jp/index.ja.html
• [Remarks]
  • URL: http://twitter.com/ShirasuLab
• [Patent(Industrial Property Rights)] 複数の病害に対して抵抗性を示す植物及びその作出法 (2009)
  • Inventor(s): 鳴坂義弘, 鳴坂真理, 白須賢
  • Industrial Property Rights Holder: 岡山県、(独) 理化学研究所
  • Industrial Property Number: 国際出願IBPF09-510WO
  • Filing Date: 2009-07-29
  • Overseas
• [Patent(Industrial Property Rights)] 植物病害抵抗性誘導剤 (2009)
  • Inventor(s): 能年義輝, 白須賢
  • Industrial Property Rights Holder: (独) 理化学研究所
  • Industrial Property Number: 国際出願PH-3949-PCT
  • Filing Date: 2009-03-27
  • Overseas
• [Patent(Industrial Property Rights)] 複数の病害に対して抵抗性を示す植物及びその作出法 (2008)
  • Inventor(s): 鳴坂義弘, 鳴坂真理, 白須賢
  • Industrial Property Rights Holder: 岡山県、(独) 理化学研究所
  • Industrial Property Number: 特許願2008-198517
  • Filing Date: 2008-07-31
• [Patent(Industrial Property Rights)] 植物病害抵抗性誘導剤 (2008)
  • Inventor(s): 能年義輝, 白須賢
  • Industrial Property Rights Holder: (独) 理化学研究所
  • Industrial Property Number: 特許願2008-88491
  • Filing Date: 2008-03-28