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2011 Fiscal Year Final Research Report

Mechanism for regulation of innate immune responses

Research Project

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Project/Area Number 19679003
Research Category

Grant-in-Aid for Young Scientists (S)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

TAKEDA Kiyoshi  大阪大学, 医学系・研究科, 教授 (20309446)

Project Period (FY) 2007 – 2011
Keywords自然免疫 / 粘膜免疫 / 炎症性疾患
Research Abstract

We analyzed the mechanisms by which activity of innate immunity is regulated using two in vivo models, protozoan parasite infections and inflammatory diseases. In infectious models, we revealed a novel mechanism in which innate immunity induces Ca2+-dependent activation of adaptive immunity. In inflammatory disease models, we used inflammatory bowel disease models, and revealed that unique subsets of intestinal innate immune myeloid cells regulate intestinal homeostasis through induction of inflammatory and anti-inflammatory responses.

  • Research Products

    (50 results)

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (26 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Intestinal CX_3C chemokine receptor 1^<high>(CX_3CR1^<high>) myeloid cells prevent T cell-dependent colitis.2012

    • Author(s)
      Kayama, H., Ueda, Y., Sawa, Y., Jeon, S. G., Ma, J. S., Okumura, R., Kubo, A., Ishii, M., Okazaki, T., Murakami, M., Yamamoto, M., Yagita, H. and Takeda, K.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 109 Pages: 5010-5015

    • Peer Reviewed
  • [Journal Article] Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP182012

    • Author(s)
      Yamamoto, M. and Takeda, K.
    • Journal Title

      Virulence

      Volume: 3 Pages: 77-80

    • Peer Reviewed
  • [Journal Article] ATF6βis a host cellular target of the Toxoplasma gondii virulence factor ROP182011

    • Author(s)
      Yamamoto, M., Ma, J. S., Mueller, C., Kamiyama, N., Saiga, H., Kubo, E., Kimura, T., Okamoto, T., Okuyama, M., Kayama, H., Nagamune, K., Takashima, S., Matsuura, Y., Soldati-Farve, D. and Takeda, K.
    • Journal Title

      J. Exp. Med.

      Volume: 208 Pages: 1533-1546

    • Peer Reviewed
  • [Journal Article] Induction of colonic regulatory T cells by indigenous Clostridium species2011

    • Author(s)
      Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., Taniguchi, T., Takeda, K., Hori, S., Ivanov, I. I., Umesaki, Y., Itoh, K., and Honda, K.
    • Journal Title

      Science

      Volume: 331 Pages: 337-341

    • Peer Reviewed
  • [Journal Article] Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10.2010

    • Author(s)
      Ueda, Y., Kayama, H., Jeon, S.-G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M. andTakeda, K.
    • Journal Title

      Int. Immunol

      Volume: 22 Pages: 953-962

    • Peer Reviewed
  • [Journal Article] The innate immune response to Trypanosoma cruzi infection.2010

    • Author(s)
      Kayama, H. and Takeda, K.
    • Journal Title

      Microbes Infect

      Volume: 12 Pages: 511-517

    • Peer Reviewed
  • [Journal Article] A novel inducible dendritic cell ablation model in mice2010

    • Author(s)
      Okuyama, M., Kayama, H., Atarashi, K., Saiga, H., Kimura, T., Waisman, A., Yamamoto, M., and Takeda, K.
    • Journal Title

      Biochem. Biophys. Res.

      Volume: 397 Pages: 559-563

    • Peer Reviewed
  • [Journal Article] A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat32009

    • Author(s)
      Yamamoto, M., Standley, D. M., Takashima, S., Saiga, H., Okuyama, M., Kayama, H., Kubo, E., Ito, H., Takaura, M., Matsuda, T., Soldati-Farve, D., and Takeda, K.
    • Journal Title

      J. Exp. Med.

      Volume: 206 Pages: 2747-2760

    • Peer Reviewed
  • [Journal Article] The lipid A receptor2009

    • Author(s)
      Takeda, K.
    • Journal Title

      Lipid A in cancer therapy

      Pages: 53-58

    • Peer Reviewed
  • [Journal Article] Induction of Intestinal Th17 cells bysegmented filamentous bacteria2009

    • Author(s)
      Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., Tanoue, T., Imaoka, A., Itoh, K., Takeda, K., Umesaki, Y., Honda, K., Littman, D. R.
    • Journal Title

      Cell

      Volume: 139 Pages: 485-498

    • Peer Reviewed
  • [Journal Article] NFATc1 mediatesToll-like receptor-independent innate immune responses during Trypanosoma cruzi infection2009

    • Author(s)
      Kayama, H., Koga, R., Atarashi, K., Mak, T. W., Takayanagi, H., Honda, K., Yamamoto, M. and Takeda, K.
    • Journal Title

      PLoS Pathogens

      Volume: 5 Pages: e1000514

    • Peer Reviewed
  • [Journal Article] C-type lectin Mincle is an activating receptorfor pathogenic fungus, Malassezia. Proc2009

    • Author(s)
      Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Takeno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., and Saito, T.
    • Journal Title

      Natl. Acad. Sci. USA

      Volume: 106 Pages: 1897-902

    • Peer Reviewed
  • [Journal Article] Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses.2009

    • Author(s)
      Morishita, H., Saito, F., Kayama, H., Atarashi, K., Kuwata, H., Yamamoto, M., and Takeda, K.
    • Journal Title

      Int. Immunol

      Volume: 21 Pages: 457-465

    • Peer Reviewed
  • [Journal Article] Regulatory mechanisms of immune responses to intestinal bacteria2009

    • Author(s)
      Honda, K., and Takeda, K.
    • Journal Title

      Mucosal Immunol

      Volume: 2 Pages: 187-196

    • Peer Reviewed
  • [Journal Article] Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium2008

    • Author(s)
      Saiga, H., Nishimura, J., Kuwata, H., Okuyama, M., Matsumoto, S., Sato, S., Matsumoto, M., Akira, S., Yoshikai, Y., Honda, K., Yamamoto, M. and Takeda, K.
    • Journal Title

      J. Immunol

      Volume: 181 Pages: 8521-8527

    • Peer Reviewed
  • [Journal Article] ATP drives lamina propria TH17 cell differentiation2008

    • Author(s)
      Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., and Takeda, K.
    • Journal Title

      Nature

      Volume: 455 Pages: 808-812

    • Peer Reviewed
  • [Journal Article] Role of nuclear IkB proteins in the regulation of host immune responses2008

    • Author(s)
      Yamamoto, M., and Takeda, K.
    • Journal Title

      J. Infect. Chemother.

      Volume: 14 Pages: 265-269

    • Peer Reviewed
  • [Journal Article] Inefficient phagosome maturation in infant macrophages2008

    • Author(s)
      Saito, F., Kuwata, H., Oike, E., Koike, M., Uchiyama, Y., Honda, K., and Takeda, K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 375 Pages: 113-118

    • Peer Reviewed
  • [Journal Article] Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IКB〓2008

    • Author(s)
      Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T., and Takeda, K.
    • Journal Title

      J. Biol. Chem.

      Volume: 283 Pages: 12468-12477

    • Peer Reviewed
  • [Journal Article] Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor2008

    • Author(s)
      Nishimura, J., Saiga, H., Sato, S., Okuyama, M., Kayama, H., Kuwata, H., Matsumoto, S., Nishida, T., Sawa, Y., Akira, S., Yoshikai, Y., Yamamoto, M., and Takeda, K.
    • Journal Title

      J. Immunol.

      Volume: 180 Pages: 4032-4039

    • Peer Reviewed
  • [Journal Article] Assessing the response of cells to TLR stimulation2008

    • Author(s)
      Takeda, K., Yamamoto, M., Honda, K.
    • Journal Title

      Signaling by Toll-like receptors

      Pages: 1-21

    • Peer Reviewed
  • [Journal Article] Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency2007

    • Author(s)
      Yamamoto, M., Uematsu, S., Okamoto, T., Matsuura, Y., Sato, S., Kumar, H., Satoh, T., Saitoh, T., Takeda, K., Ishii, K. J., Takeuchi, O., Kawai, T., and Akira, S.
    • Journal Title

      J. Exp. Med.

      Volume: 204 Pages: 2233-2239

    • Peer Reviewed
  • [Presentation] Regulatory Mechanisms of Immune Responses to Intestinal Bacteria2012

    • Author(s)
      Kiyoshi Takeda, Hisako Kayama
    • Organizer
      Keystone Symposium
    • Place of Presentation
      Keystone, USA
    • Year and Date
      20120304-08
  • [Presentation] Regulation of gut homeostasis by microbiota and innate immunity2012

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The 4^<th> Symposium of Immunological Self
    • Place of Presentation
      Kyoto
    • Year and Date
      20120127-28
  • [Presentation] Regulation of gut homeostasis by microbiota and innate immunity2011

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      Joint Symposium of CRCID
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20111219-20
  • [Presentation] A unique subset of intestinal myeloid cells suppress T cell-dependent intestinal inflammation2011

    • Author(s)
      Kiyoshi Takeda, Hisako Kayama
    • Organizer
      第40回日本免疫学会学術集会(シンポジウム)
    • Place of Presentation
      千葉
    • Year and Date
      20111127-29
  • [Presentation] Regulation of intestinal homeostasis by innate immunity2011

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      日本食品免疫学会第7回学術大会
    • Place of Presentation
      東京
    • Year and Date
      20111018-19
  • [Presentation] 自然免疫と炎症性疾患2011

    • Author(s)
      竹田潔
    • Organizer
      第48回日本眼感染症学会
    • Place of Presentation
      京都
    • Year and Date
      20110708-10
  • [Presentation] Regulation of intestinal homeostasis by innate immunity2011

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The NZ Australian Society for Immunology Branch Meeting 2011
    • Place of Presentation
      Welington New Zealand
    • Year and Date
      20110630-07
  • [Presentation] Regulation of intestinal homeostasis by innate immunity2011

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      ESF-JSPSFrontier Science Conference for Young Researchers
    • Place of Presentation
      Hulshort, The Netherlands
    • Year and Date
      20110301-06
  • [Presentation] Innate immune responses at the intestinal mucosa2010

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      Annual Meeting of The Society for Leukocyte Biology & The International Endotoxin and Innate Immunity Society
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      20101007-09
  • [Presentation] Regulation of innate immune responses at the intestinal mucosa2010

    • Author(s)
      Kiyoshi Takeda, Hisako Kayama
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      20100822-27
  • [Presentation] Regulation of innate immune responses at the, intestinal mucosa.2010

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      Host-Pathogen interactions in generalized bacterial infection
    • Place of Presentation
      Greifswald, Germany
    • Year and Date
      20100531-0603
  • [Presentation] Regulation of intestinal homeostasis by innate immunity2010

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20100327-29
  • [Presentation] 腸管粘膜に特有の自然免疫系細胞の機能(ランチョンセミナー)2009

    • Author(s)
      竹田潔
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      20091202-04
  • [Presentation] 自然免疫系の活性制御と免疫疾患(特別講演)2009

    • Author(s)
      竹田潔
    • Organizer
      第51回日本小児血液学会
    • Place of Presentation
      東京
    • Year and Date
      20091127-29
  • [Presentation] Innate immune responses at the intestinal mucosa2009

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The 2009 Fall Conference of the Korean Association of Immunologists
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      20091109-10
  • [Presentation] Innate immune responses at the intestinal mucosa2009

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The first CSI/ JSI/ KAI Join Symposium on Immunology
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20091107-08
  • [Presentation] トリパノソーマ原虫に対する自然免疫応答機構2009

    • Author(s)
      竹田潔
    • Organizer
      第20回日本生体防御学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      20090725-26
  • [Presentation] Commensal bacteria-derived ATP mediates development of intestinal Th17 cells2009

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      RCAI-JSI International Symposium on Immunology 2009
    • Place of Presentation
      横浜
    • Year and Date
      20090709-10
  • [Presentation] Masahiro Yamamoto NFAT is responsible for TLR-independent innate immune responses to a protozoan parasite2008

    • Author(s)
      Kiyoshi Takeda, Hisako Kayama
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      20081209-12
  • [Presentation] A mechanism for development of intestinal Th17 cells causing intestinal inflammation2008

    • Author(s)
      Kiyoshi Takeda, Koji Atarashi, Kenya Honda
    • Organizer
      The 7^<th> Sino-Japan Joint Conference for Cancer Research
    • Place of Presentation
      Guangzhou, China
    • Year and Date
      20081207-10
  • [Presentation] Commensal bacteria-derived ATP mediates Th17 cell development in the intestinal lamina propria(Symposium)2008

    • Author(s)
      Kiyoshi Takeda, Koji Atarashi, Kenya Honda
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      20081201-03
  • [Presentation] 自然免疫系と炎症性腸疾患2008

    • Author(s)
      竹田潔
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
  • [Presentation] Regulatory mechanisms of innate immune responses2008

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The Kick-off Symposium on the MEXT Priority Research for Immunological Self
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-02-28
  • [Presentation] Regulation of innate immune responses2007

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      The 9^<th> International Colooquium on Paratuberculosis
    • Place of Presentation
      Tsukuba, Japan
    • Year and Date
      2007-10-29
  • [Presentation] Regulation of inflammatory responses by nuclear IkB proteins2007

    • Author(s)
      Kiyoshi Takeda
    • Organizer
      8th International Society of Exercise and Immunology Symposium
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2007-10-25
  • [Presentation] 自然免疫シグナルの制御機構2007

    • Author(s)
      竹田潔
    • Organizer
      第28回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2007-08-02
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/ongene/

  • [Patent(Industrial Property Rights)] T細胞活性化を抑制する腸粘膜特有のミエロイド細胞およびその利用2009

    • Inventor(s)
      香山尚子、竹田潔
    • Industrial Property Rights Holder
      大阪大学、科学技術振興機構
    • Industrial Property Number
      特許、特願2009-241034
    • Filing Date
      2009-10-20

URL: 

Published: 2013-07-31  

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