2011 Fiscal Year Final Research Report
Elucidation of molecular pathogenesis and therapeutic targets for refractory hematological malignancies
| Project/Area Number |
19679004
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KUROKAWA Mineo 東京大学, 医学部・附属病院, 教授 (80312320)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 白血病 / 造血幹細胞 / 白血病幹細胞 / 血液腫瘍学 |
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| Research Abstract |
In this study, we demonstrated that the epigenetic regulation of transcription by Evi-1 is essential for its leukemogenic capacity. We also revealed the novel molecular mechanisms by which the loss-of-function of AML1 promotes leukemogenesis, using our Aml1 conditional knockout mice. Furthermore, using newly generated Evi-1 conditional knockout mice and Evi-1-ires-GFP knock-in mice, we demonstrated a distinctive relationship between Evi-1 and the phenotype of hematopoietic stem cells or leukemic stem cells. These results provide a foundation to develop novel molecular targeted therapies for refractory hematological malignancies.
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