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2009 Fiscal Year Final Research Report

Spontaneous Symmetry Breaking Mechanism in Biological Morphology

Research Project

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Project/Area Number 19680014
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Bioinformatics/Life informatics
Research InstitutionNara Institute of Science and Technology

Principal Investigator

SAKUMURA Yuichi  Nara Institute of Science and Technology, 情報科学研究科, 特任准教授 (50324968)

Project Period (FY) 2007 – 2009
Keywordsシステム生物学 / 分子生物学 / 形態形成 / シグナル伝達
Research Abstract

Developing neuron has several immature neurites with similar length and elongates one of neurites which becomes axon. In the development of vertebrates, the epithelized cell group called as somite is formed in uniformly distributed cell group. These symmetry breaking phenomena were studied with collaborators in experimental field by constructing mathematical model. In each study, novel mechanism was discovered and predictions from mathematical model were validated by experiments.

  • Research Products

    (22 results)

All 2010 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Remarks (5 results)

  • [Journal Article] 細胞形態変化の定量と現象論的モデル2010

    • Author(s)
      塚田祐基, 作村諭一
    • Journal Title

      細胞工学(秀潤社)

      Pages: 339-343

  • [Journal Article] Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse2009

    • Author(s)
      Hayashi S, Shimoda T, Nakajima M, Tsukada Y, Sakumura Y, Dale JK, Maroto M, Kohno K, Matsui T, Bessho Y.
    • Journal Title

      PSM. PToS One 4(5)

      Pages: e5603

    • Peer Reviewed
  • [Journal Article] Quantification of local morphodynamics and local GTPase activity by edge evolution tracking2008

    • Author(s)
      Tsukada Y, Aoki K, Nakamura T, Sakumura Y, Matsuda M, Ishii S.
    • Journal Title

      PToS Comput. Biol. 4(11)

      Pages: e1000223

    • Peer Reviewed
  • [Journal Article] Stochastic Control of Spontaneous Signal Generation for Gradient Sensing in Chemotaxis2008

    • Author(s)
      Honda N, Sakumura Y, Ishii S.
    • Journal Title

      J. Theor. 255

      Pages: 259-266

    • Peer Reviewed
  • [Journal Article] A Diffusion-based neurite length sensing mechanism involved in neuronal symmetry-breaking

    • Author(s)
      Toriyama M, *Sakumura Y, Shimada T, Ishii S, *Inagaki N
    • Journal Title

      Molecular Systems Biology (in press)

    • Peer Reviewed
  • [Presentation] 独立成分分析を用いた初期視覚野の二重反対色同心円型受容野の形成2010

    • Author(s)
      青木孝剛, 五十嵐康伸, 木村塁, 今基織, 作村諭一, 石井信
    • Place of Presentation
      玉川大学
    • Year and Date
      20100300
  • [Presentation] 統計的手法を用いた神経軸索の形態予測2009

    • Author(s)
      内海将人, 作村諭一, 福西昭子, 山本亘彦, 石井信
    • Organizer
      電子情報通信学会技術研究報告
    • Place of Presentation
      玉川大学
    • Year and Date
      20090300
  • [Presentation] 脊椎動物の発達過程における分節時計の分子システム2009

    • Author(s)
      伊坂弥花子, 山尾将隆, 作村諭一, 金雄, 松井貴輝, 別所康全, 石井信
    • Place of Presentation
      京都市
    • Year and Date
      20090300
  • [Presentation] A quantitative modeling of neural morphological polarization2009

    • Author(s)
      Sakumura Y
    • Organizer
      Asia Simulation Conference(JSST2009)
    • Place of Presentation
      同志社大学
    • Year and Date
      20090000
  • [Presentation] A quantitative description of polarization in neural morphology2008

    • Author(s)
      Sakumura Y, Toriyama M, Inagaki N, Ishii S
    • Organizer
      バイオスーパーコンピューティング・シンポジゥム(BSCS)
    • Place of Presentation
      東京丸の内
    • Year and Date
      20081200
  • [Presentation] A quantitative mathematical description of neural polarity2008

    • Author(s)
      Sakumura Y
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸市(シンポジウム)
    • Year and Date
      20081200
  • [Presentation] Rho/Rho-kinaseによるミオシンの動的リン酸化制御システム2008

    • Author(s)
      河野(金兒)貴子, 本田直樹, 塚田祐基, 山尾将隆, 作村諭一, 石井信
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      20081200
  • [Presentation] On the synchrony of morphological and molecular signaling events in cell migration2008

    • Author(s)
      Dauwels, J., Tsukada, Y., Sakumura, Y., Ishii, S., Aoki, K., Nakamura, T., Matsuda, M., Vialatte, F., Cichocki, A.
    • Organizer
      International Conference on Neural Information Processing (ICONIP2008)
    • Place of Presentation
      オークランドニュージーランド
    • Year and Date
      20081200
  • [Presentation] Quantitative Morphodynamic Analysis of FRET time-lapse imaging2008

    • Author(s)
      Tsukada, Y., Aoki, K., Sakumura, Y., Nakamura, T., Matsuda, M., Ishii, S.
    • Organizer
      International Conference on Systems Biology (ICSB 2008)
    • Place of Presentation
      ヨーテボリスウェーデン
    • Year and Date
      20080800
  • [Presentation] シグナル伝達の拡散と局所性を利用したシナプス可塑性2007

    • Author(s)
      作村諭一
    • Organizer
      2007年度シナプス研究会
    • Place of Presentation
      生理学研究所
    • Year and Date
      20071200
  • [Presentation] Quantitative Morphodynamic Analysis of Time-Lapse Imaging by Edge Evolution Tracking2007

    • Author(s)
      Tsukada, Y., Sakumura, Y., Ishii, S.
    • Organizer
      International Conference on Neural Information Processing (ICONIP 2007)
    • Place of Presentation
      北九州
    • Year and Date
      20071100
  • [Presentation] Spontaneous signal generation induced by reaction noise for gradient sensing in chemotaxi s2007

    • Author(s)
      Naoki, H., Sakumura, Y., Ishii, S.
    • Organizer
      International Conference of Systems Biology (ICSB 2007)
    • Place of Presentation
      米国カリフォルニア州
    • Year and Date
      20071000
  • [Remarks] 本研究課題と関係する国内外の研究者を招聘し、ワークショップ(システム神経生物学スプリングスクール)を開催した。

  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2007

  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2008

  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2009

  • [Remarks]

    • URL

      http://nippon.naist.jp/SNSS2010

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Published: 2011-06-18   Modified: 2016-04-21  

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