2009 Fiscal Year Final Research Report
Regulation of gamma-secretase activity
Project/Area Number |
19680019
|
Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Nerve anatomy/Neuropathology
|
Research Institution | Doshisha University |
Principal Investigator |
FUNAMOTO Satoru Doshisha University, 生命医科学部, 准教授 (10345043)
|
Project Period (FY) |
2007 – 2009
|
Keywords | アルツハイマー病 / アミロイドβタンパク質 / ガンマセクレターゼ / プレセニリン / ホスフォイノシチド |
Research Abstract |
γ-Secretase is an aspartic protease to hydrolyze type I transmembrane protein in hydrophobic environment of lipid bilayer. In this study, we analyzed effects of phosphoinositides on γ-secretase activity. We found that phosphoinositides inhibitedγ-secretase activity in the CHAPSO-solubilized assay system and detergent insoluble fraction, in dose dependent manner.
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